发表一篇学和医学成像类SCI论文
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Abstract:
OBJECTIVE:To evaluate the efficacy and safety of Chinese medicine (CM) improving pregnancy outcomes after surgery for endometriosis-associated infertility. METHODS:A multicenter, randomized, double-blind placebo parallel controlled clinical trial was designed. A total of 202 patients who had laparoscopy for endometriosis-associated infertility with qi stagnation and blood stasis syndrome were included and randomly divided into the CM treatment group and placebo control group at a ratio of 1:1 using a central block randomization from May 2014 to September 2017, 101 patients in each group. The two groups received continuous intervention at 1-5 days after surgery, for 6 menstrual cycles. Before ovulation, the CM group was treated Huoxue Xiaoyi Granule (); after ovulation, Bushen Zhuyun Granule ( was involved. The control group was treated with placebo. Transvaginal ultrasonography was performed every menstrual cycle during the treatment, and female hormone levels in the follicular and luteal phases were measured during the 1st, 3rd and 6th menstrual cycles. The analysis was continued until pregnancy. The primary outcomes were clinical pregnancy rate and pregnancy outcome, and the secondary outcomes were follicular development and endometrial receptivity. Safety evaluations were performed before and after treatment. RESULTS:(1) Clinical pregnancy and live birth rates: the clinical pregnancy and live birth rates of the CM group were significantly higher than those of the placebo group [44.6% (45/101) vs. 29.7% (30/101), 34.7% (35/101) vs. 20.8% (21/101), both P<0.05]. (2) Follicle development: the incidence of dominant follicles, rate of cumulative cycle ovulation, and rate of cumulative cycle mature follicle ovulation were significantly higher in the CM group than those in the placebo group [93.8% (350/373) vs. 89.5% (341/381), 80.4% (275/342) vs. 69.1% (253/366), 65.8% (181/275) vs 56.1% (142/253), P<0.05 or P<0.01]). The incidence of cumulative cycle luteinized unruptured follicle syndrome was significantly lower in the CM group than in the placebo group [11.7% (40/342) vs. 17.8% (65/366), P<0.05). (3) Endometrial receptivity: after treatment, both endometrial types and endometrial blood flow types in the CM group were mainly types A and B, while those in the placebo group were mainly types B and C, with a significant difference between the two groups (both P<0.05). (4) Adverse events: the incidence of adverse events between the two groups was not significantly different (P>0.05). CONCLUSION:Strategies for activating blood circulation-regulating Gan (Liver)-tonifying Shen (Kidney) sequential therapy can effectively improve the clinical pregnancy rate and live birth rate of endometriosis-associated infertility with qi stagnation and blood stasis after laparoscopy, improve follicular development, promote ovulation, improve endometrial receptivity, while being a safe treatment option. (Trial registration No. NCT02676713).
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最新影响因子:2.626 | 期刊ISSN:1672-0415 | CiteScore:1.05 |
出版周期:Quarterly | 是否OA:YES | 出版年份:2003 |
自引率:5.50% | 研究方向:医学-全科医学与补充医学 |
出版地区:PEOPLES R CHINA |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Chinese Journal of Integrative Medicine seeks to promote international communication and exchange on integrative medicine as well as complementary and alternative medicine (CAM) and provide a rapid forum for the dissemination of scientific articles focusing on the latest developments and trends as well as experiences and achievements on integrative medicine or CAM in clinical practice, scientific research, education and healthcare.
《中国结合医学杂志》旨在促进国际交流和交换结合医学以及补充和替代医学(CAM),并提供一个快速的传播科学论坛文章关注最新的技术进展和趋势以及经验和成果结合医学或凸轮在临床实践中,科学研究、教育和医疗。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
INTEGRATIVE & COMPLEMENTARY MEDICINE(综合和补充性医学) 4区 |
18/27 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
126 | 117 | 9 |
引文计数(2018)
文献(2015-2017)
424次引用
403篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Complementary and Alternative Medicine
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#33/91
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2 |
大类(学科):Medicine
小类(学科):Pharmacology (medical)
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#140/230
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研究方向:oncology
审稿时间: 12个月内
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研究方向:中医
审稿时间: 3个月内
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研究方向:中医 天然药物
审稿时间: 6个月内 接受率: 中等(50%命中)
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研究方向:中医临床
审稿时间: 2个月内 接受率: 中等(50%命中)
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审稿时间: 3个月内 接受率: 一般容易(75%命中)
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研究方向:中医
审稿时间: 6个月内
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研究方向:antiviral research
审稿时间: 3个月内 接受率: 一般容易(75%命中)
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研究方向:中医 中药复方
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接受率: 一般容易(75%命中)
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影响因子:1.714
ISSN:1386-2073
研究方向:化学-生化研究方法
影响因子:6.088
ISSN:1933-7213
研究方向:医学-神经科学
影响因子:1.379
ISSN:0362-5664
研究方向:医学-临床神经学
影响因子:4.287
ISSN:1473-7175
研究方向:CLINICAL NEUROLOGY-PHARMACOLOGY & PHARMACY
影响因子:1.821
ISSN:1528-4336
研究方向:医学-传染病学
影响因子:2.385
ISSN:1120-009X
研究方向:医学-药学
影响因子:2.706
ISSN:1076-6294
研究方向:医学-传染病学
影响因子:4.177
ISSN:1178-6973
研究方向:-
影响因子:5.758
ISSN:0305-7453
研究方向:医学-传染病学
发表一篇学和医学成像类SCI论文
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