发表一篇学和医学成像类SCI论文
需要多少钱?
Abstract:
:The balance of excitation and inhibition is essential for cortical information processing, relying on the tight orchestration of the underlying subcellular processes. Dynamic transcriptional control by DNA methylation, catalyzed by DNA methyltransferases (DNMTs), and DNA demethylation, achieved by ten-eleven translocation (TET)-dependent mechanisms, is proposed to regulate synaptic function in the adult brain with implications for learning and memory. However, focus so far is laid on excitatory neurons. Given the crucial role of inhibitory cortical interneurons in cortical information processing and in disease, deciphering the cellular and molecular mechanisms of GABAergic transmission is fundamental. The emerging relevance of DNMT and TET-mediated functions for synaptic regulation irrevocably raises the question for the targeted subcellular processes and mechanisms. In this study, we analyzed the role dynamic DNA methylation has in regulating cortical interneuron function. We found that DNMT1 and TET1/TET3 contrarily modulate clathrin-mediated endocytosis. Moreover, we provide evidence that DNMT1 influences synaptic vesicle replenishment and GABAergic transmission, presumably through the DNA methylation-dependent transcriptional control over endocytosis-related genes. The relevance of our findings is supported by human brain sample analysis, pointing to a potential implication of DNA methylation-dependent endocytosis regulation in the pathophysiology of temporal lobe epilepsy, a disease characterized by disturbed synaptic transmission.
展开更多
最新影响因子:4.861 | 期刊ISSN:1047-3211 | CiteScore:5.87 |
出版周期:Monthly | 是否OA:YES | 出版年份:1991 |
期刊官方网址:http://cercor.oxfordjournals.org/
期刊投稿地址:http://www.oxfordjournals.org/our_journals/cercor/for_authors/submission_online.html
自引率:5.20% | 研究方向:医学-神经科学 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
专业编辑在线一对一答疑及时解决您的问题
Cerebral Cortex publishes papers on the development organization plasticity and function of the cerebral cortex including the hippocampus. Studies with clear relevance to the cerebral cortex such as the thalamocortical relationship or cortico-subcortical interactions are also included. The journal is multidisciplinary and covers the large variety of modern neurobiological and neuropsychological techniques including anatomy biochemistry molecular neurobiology electrophysiology behavior artificial intelligence and theoretical modeling. In addition to research articles special features such as brief reviews book reviews and commentaries are included. Cerebral Cortex is published 8 times yearly.
《大脑皮层》发表关于大脑皮层包括海马的发育、组织、可塑性和功能的论文。与大脑皮层有明显相关性的研究,如丘脑皮质关系或皮质-皮质下相互作用也包括在内。该杂志是多学科的,涵盖了多种现代神经生物学和神经心理学技术,包括解剖学、生物化学、分子神经生物学、电生理学、行为、人工智能和理论建模。除了研究文章,特别功能,如简要评论,书评和评论包括。《大脑皮层》每年出版8期。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
NEUROSCIENCES (神经科学) 2区 |
24/261 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
441 | 441 | 0 |
引文计数(2018)
文献(2015-2017)
6274次引用
1068篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Neuroscience
小类(学科):Cognitive Neuroscience
|
#6/90
点击查看排名表
|
|
2 |
大类(学科):Neuroscience
小类(学科):Cellular and Molecular Neuroscience
|
#8/85
点击查看排名表
|
|
推荐刊物均可到国家新闻出
版总署网站查询正刊
可签署保密协议 ,不透露任
何用户信息可跟踪进程,全程
协议
1对1服务,7x24小时在线
15年经验沉淀,实体公司
运营
liting7111
研究方向:医药科学 神经系统 精神疾病 神经症 应激相关障碍
审稿时间: 1个月内
liting7111
研究方向:生命科学 神经科学 认知科学 心理学
审稿时间: 3个月内
liting7111
研究方向:生命科学 神经科学 认知科学 心理学 神经生物学
审稿时间: 1个月内
liting7111
研究方向:神经科学
审稿时间: 2个月内 接受率: 比较困难(25%命中)
影响因子:13.029
ISSN:1522-8517
研究方向:医学-临床神经学
影响因子:4.506
ISSN:0167-594X
研究方向:医学-临床神经学
影响因子:7.723
ISSN:2162-402X
研究方向:ONCOLOGYIMMUNOLOGY-IMMUNOLOGY
影响因子:4.912
ISSN:1524-9557
研究方向:医学-免疫学
影响因子:12.02
ISSN:2326-6066
研究方向:ONCOLOGY-IMMUNOLOGY
影响因子:3.698
ISSN:1750-9378
研究方向:ONCOLOGY-IMMUNOLOGY
影响因子:6.63
ISSN:0340-7004
研究方向:医学-免疫学
影响因子:3.077
ISSN:1534-7354
研究方向:医学-全科医学与补充医学
影响因子:0
ISSN:1868-8497
研究方向:ONCOLOGY-ENDOCRINOLOGY & METABOLISM
发表一篇学和医学成像类SCI论文
需要多少钱?
专注医学期刊服务15年
您好:请问您咨询什么等级的期刊?专注医学类期刊发表15年口碑企业,为您提供以下服务:
1.医学核心期刊发表-全流程服务
2.医学SCI期刊-全流程服务
3.论文投稿服务-快速报价
4.期刊推荐直至录用,不成功不收费
客服正在输入...
CEREBRAL CORTEX 投稿经验
(由下方点评分析获得,4人参与,33648人阅读)