发表一篇学和医学成像类SCI论文
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Abstract:
:Herein field recordings were utilized to test the effects of a transient period of pentylenetetrazol (PTZ) treatment on theta-burst long-term potentiation (LTP) at the Schaffer collateral-CA1 synapses as well as RT-PCR was used to investigate the effects of the combination of the pharmacological treatment and the theta-burst LTP induction on the expression of NMDA subunit mRNA in hippocampal slices. The slope of field excitatory postsynaptic potential (fEPSP) was unaffected while the population spike amplitude and area were increased by a transient period of PTZ treatment (3 mM, 10 min). After a theta burst, a brief PTZ exposure can lead to an enhancement of LTP as documented by fEPSP recording. The effect can be blocked by a selective NMDA receptor antagonist DL-AP5. An increase in the expression of GluN2B and GluN2A subunit mRNAs was also shown due to the combined treatment. The results indicate that the combined treatment increases the degree of NMDA-dependent LTP and are in accord with literature data on the subunit alterations of the hippocampal NMDA receptors. Moreover, our experimental paradigm can be used as a new approach to study the relevance of LTP-like phenomena and epileptic mechanisms.
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最新影响因子:2.064 | 期刊ISSN:0014-4819 | CiteScore:2.02 |
出版周期: | 是否OA:YES | 出版年份:0 |
期刊官方网址:http://www.springer.com/biomed/neuroscience/journal/221
自引率:11.50% | 研究方向:NEUROSCIENCES- |
出版地区:GERMANY |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Experimental Brain Research was founded in 1966. Editorial Board: P. Dell J.C. Eccles D.M. MacKay D. Ploog J. Szentágothai H. Waelsch. Experimental Brain Research accepts original contributions on many aspects of experimental research of the central and peripheral nervous system in the fields of molecular physiology behaviour neurochemistry developmental cellular and molecular neurobiology and experimental pathology relevant to general problems of cerebral function. Full-length papers as well as short research notes can be submitted.
脑实验研究成立于1966年。编委会:P. Dell J.C. Eccles D.M. MacKay D. Ploog J. Szentagothai H. Waelsch。脑实验研究在分子生理、行为、神经化学、发育、细胞和分子神经生物学以及与脑功能一般问题相关的实验病理学等方面对中枢和外周神经系统的实验研究做出了许多开创性的贡献。完整的论文以及简短的研究笔记都可以提交。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
NEUROSCIENCES (神经科学) 4区 |
211/261 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
324 | 312 | 12 |
引文计数(2018)
文献(2015-2017)
2077次引用
1029篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Neuroscience
小类(学科):General Neuroscience
|
#61/111
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研究方向:医药科学 神经系统 精神疾病 意识障碍
审稿时间: 1个月内
liting7111
研究方向:神经影像学
审稿时间: 2个月内 接受率: 中等(50%命中)
影响因子:13.029
ISSN:1522-8517
研究方向:医学-临床神经学
影响因子:4.506
ISSN:0167-594X
研究方向:医学-临床神经学
影响因子:7.723
ISSN:2162-402X
研究方向:ONCOLOGYIMMUNOLOGY-IMMUNOLOGY
影响因子:4.912
ISSN:1524-9557
研究方向:医学-免疫学
影响因子:12.02
ISSN:2326-6066
研究方向:ONCOLOGY-IMMUNOLOGY
影响因子:3.698
ISSN:1750-9378
研究方向:ONCOLOGY-IMMUNOLOGY
影响因子:6.63
ISSN:0340-7004
研究方向:医学-免疫学
影响因子:3.077
ISSN:1534-7354
研究方向:医学-全科医学与补充医学
影响因子:0
ISSN:1868-8497
研究方向:ONCOLOGY-ENDOCRINOLOGY & METABOLISM
发表一篇学和医学成像类SCI论文
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