发表一篇学和医学成像类SCI论文
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Abstract:
Purpose There is limited evidence on the efficacy and safety of anti-programmed cell death protein 1 (PD-1)-/anti-programmed death-ligand 1 (PD-L1)-based immunotherapy in the elderly, particularly those aged over 75 years. Methods/patients The clinical response and toxicity profile of anti-PD-1-/anti-PD-L1-based immunotherapy in patients aged over 75 years were assessed in this retrospective observational study conducted in the Medical Oncology Service of a tertiary level hospital. The associations among clinical responses, adverse events, and geriatric syndromes were evaluated. Results In total, 20 patients aged between 75 and 94 years were evaluated. Pembrolizumab and nivolumab were the most commonly used drugs. A clinical benefit (stable disease, partial response or complete response) was documented in 13 patients (65%). This proportion was 80% in patients aged between 75 and 79 years, and 50% in those aged over 79 years ( p = 0.236). The adverse events were similar to those reported in younger patients. At least one clinical adverse event (cAE) and one laboratory adverse event (lAE) was reported in 75% and 55% of patients, respectively. Polypharmacy was observed for all patients and multi-morbidity in 95%. Patients without gait disorders showed more responses to immunotherapy. The number of lAEs was significantly associated with the number of commonly prescribed drugs (slope = 0.218, p = 0.010), the Eastern Cooperative Oncology Group score, and the number of cAEs. Conclusions The elderly can obtain benefits from anti-PD-1-/anti-PD-L1-based immunotherapy . The toxicity profile was similar to that reported in younger counterparts.
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最新影响因子:3.34 | 期刊ISSN:1699-048X | CiteScore:5.16 |
出版周期:Monthly | 是否OA:YES | 出版年份:2005 |
自引率:2.20% | 研究方向:医学-肿瘤学 |
出版地区:SPAIN |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Clinical and Translational Oncology is an international journal devoted to fostering interaction between experimental and clinical oncology. It covers all aspects of research on cancer, from the more basic discoveries dealing with both cell and molecular biology of tumour cells, to the most advanced clinical assays of conventional and new drugs. In addition, the journal has a strong commitment to facilitating the transfer of knowledge from the basic laboratory to the clinical practice, with the publication of educational series devoted to closing the gap between molecular and clinical oncologists. Molecular biology of tumours, identification of biomarkers for cancer diagnosis, prognosis or prediction of treatment response, identification of new targets for cancer therapy, as well as development of new technologies for research and treatment of cancer are the major themes covered by both the educational series and research articles. A broad spectrum of subjects, including the molecular and cellular bases of disease, aetiology, pathophysiology, pathology, epidemiology, clinical features, and the diagnosis, prognosis and treatment of cancer, will be considered for publication.
《临床与转化肿瘤学》是一本致力于促进实验肿瘤学与临床肿瘤学相互作用的国际期刊。它涵盖了癌症研究的所有方面,从涉及肿瘤细胞和分子生物学的更基本的发现,到最先进的传统和新药的临床检测。此外,该杂志致力于促进从基础实验室到临床实践的知识转移,出版了一系列致力于缩小分子肿瘤学家和临床肿瘤学家之间差距的教育系列。肿瘤分子生物学、癌症诊断生物标记物的识别、治疗反应的预后或预测、癌症治疗新靶点的识别以及癌症研究和治疗新技术的开发是教育系列和研究文章的主题。将考虑发表广泛的主题,包括疾病的分子和细胞基础、病因学、病理生理学、病理学、流行病学、临床特征以及癌症的诊断、预后和治疗。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
ONCOLOGY (肿瘤学) 4区 |
156/223 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
179 | 144 | 35 |
引文计数(2018)
文献(2015-2017)
8579次引用
1661篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Pulmonary and Respiratory Medicine
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研究方向:肿瘤 癌症
审稿时间: 2个月内
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研究方向:肿瘤 癌症
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研究方向:肿瘤 癌症
审稿时间: 2个月内 接受率: 中等(50%命中)
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研究方向:meta
审稿时间: 2个月内 接受率: 比较困难(25%命中)
liting7111
审稿时间: 2个月内 接受率: 中等(50%命中)
影响因子:2.566
ISSN:0739-7240
研究方向:农林科学-奶制品与动物科学
影响因子:6.497
ISSN:1172-7047
研究方向:医学-精神病学
影响因子:1.297
ISSN:0028-2804
研究方向:医学-精神病学
影响因子:4.604
ISSN:1092-8529
研究方向:医学-精神病学
影响因子:5.345
ISSN:1398-5647
研究方向:医学-精神病学
影响因子:3.492
ISSN:1540-2002
研究方向:CLINICAL NEUROLOGY-PSYCHIATRY
影响因子:4.562
ISSN:0269-8811
研究方向:医学-精神病学
影响因子:6.533
ISSN:0165-0327
研究方向:医学-精神病学
影响因子:5.415
ISSN:0924-977X
研究方向:医学-精神病学
发表一篇学和医学成像类SCI论文
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