发表一篇学和医学成像类SCI论文
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Abstract:
:Immune checkpoint inhibitors have drawn a consider attention as an effective cancer immunotherapy, and several monoclonal antibodies targeting the immune checkpoint receptors, such as human programmed cell death-1 (hPD-1) and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4), are clinically used for treatment of various cancers. Here we present the development of a small-sized protein binder which specifically binds to hPD-1. The protein binder, which is composed of leucine-rich repeat (LRR) modules, was selected against hPD-1 through phage display, and its binding affinity was maturated up to 17 nM by modular evolution approach. The protein binder was shown to be highly specific for hPD-1, effectively inhibiting the interaction between hPD-1 and its ligand, hPD-L1. The protein binder restored T-cell function in vitro, and exhibited a strong anti-tumour activity in tumour mouse model, indicating that it acts as an effective checkpoint blockade. Based on the results, the developed protein binder specific for hPD-1 is likely to find a potential use in cancer immunotherapy.
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最新影响因子:5.016 | 期刊ISSN:1061-186X | CiteScore:2.85 |
出版周期:Bimonthly | 是否OA:YES | 出版年份:1993 |
自引率:2.90% | 研究方向:医学-药学 |
出版地区:ENGLAND |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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The Journal of Drug Targeting publishes papers and reviews on all aspects of drug delivery and targeting for molecular and macromolecular drugs including the design and characterization of carrier systems (whether colloidal, protein or polymeric) for both vitro and/or in vivo applications of these drugs. Papers are not restricted to drugs delivered by way of a carrier, but also include studies on molecular and macromolecular drugs that are designed to target specific cellular or extra-cellular molecules. As such the journal publishes results on the activity, delivery and targeting of therapeutic peptides/proteins and nucleic acids including genes/plasmid DNA, gene silencing nucleic acids (e.g. small interfering (si)RNA, antisense oligonucleotides, ribozymes, DNAzymes), as well as aptamers, mononucleotides and monoclonal antibodies and their conjugates. The diagnostic application of targeting technologies as well as targeted delivery of diagnostic and imaging agents also fall within the scope of the journal. In addition, papers are sought on self-regulating systems, systems responsive to their environment and to external stimuli and those that can produce programmed, pulsed and otherwise complex delivery patterns. The Journal of Drug Targeting also carries papers on the physiological and other biological barriers to delivery and targeting, and means of overcoming the barriers, for example, by penetration enhancers, and covers subjects such as extravasation, diffusion in tumours and target tissues, avoidance of the reticulo-endothelial system, and toxicity testing and licensing of novel delivery systems.
《药物靶向》杂志发表了关于药物传递和分子和大分子药物靶向的所有方面的论文和评论,包括为这些药物的体外和/或体内应用设计和表征载体系统(胶体、蛋白质或聚合物)。论文不仅限于通过载体传递药物,还包括针对特定细胞或细胞外分子的分子和大分子药物的研究。因此,该杂志发表了包括基因/质粒DNA、基因沉默核酸(如小干扰RNA、反义寡核苷酸、核糖酶、DNAzymes)、适配体、单核苷酸和单克隆抗体及其偶联物在内的治疗肽/蛋白质和核酸的活性、传递和靶向性的研究结果。目标技术的诊断应用以及诊断和显像剂的靶向交付也属于该杂志的范围。此外,还寻求关于自我调节系统、对环境和外部刺激作出反应的系统以及能够产生程控、脉冲和其他复杂传递模式的系统的论文。药物杂志的目标也有论文的生理和其他生物障碍交付和定位,和手段,克服障碍,例如,通过渗透增强剂,并涵盖科目如溢出,在肿瘤扩散和目标组织,避免网状内皮系统,和小说交付系统的毒性测试和许可。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
PHARMACOLOGY & PHARMACY (药学) 3区 |
71/261 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
85 | 68 | 17 |
引文计数(2018)
文献(2015-2017)
780次引用
274篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Pharmacology, Toxicology and Pharmaceutics
小类(学科):Pharmaceutical Science
|
#34/174
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研究方向:药物靶点
审稿时间: 2个月内 接受率: 一般容易(75%命中)
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审稿时间: 2个月内
影响因子:0.753
ISSN:0534-0012
研究方向:AGRONOMY-GENETICS & HEREDITY
影响因子:1.282
ISSN:0037-5349
研究方向:农林科学-林学
影响因子:3.017
ISSN:1364-6745
研究方向:医学-临床神经学
影响因子:3.469
ISSN:1475-2875
研究方向:医学-寄生虫学
影响因子:0.735
ISSN:0972-9062
研究方向:INFECTIOUS DISEASES-PARASITOLOGY
影响因子:0.209
ISSN:0125-1562
研究方向:PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH-INFECT
影响因子:1.794
ISSN:0142-6338
研究方向:医学-热带医学
影响因子:0.828
ISSN:0049-4755
研究方向:医学-公共卫生、环境卫生与职业卫生
影响因子:3.918
ISSN:1360-2276
研究方向:医学-公共卫生、环境卫生与职业卫生
发表一篇学和医学成像类SCI论文
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