发表一篇学和医学成像类SCI论文
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Abstract:
BACKGROUND:Patients with mechanical heart valves are still not eligible for treatment with direct oral anticoagulants (DOAC). We aimed to conduct a proof-of-principle study investigating the anti-Xa inhibitor rivaroxaban as antithrombotic treatment in patients with recent mechanical aortic valve replacement. MATERIALS AND METHODS:Low-risk patients scheduled for elective mechanical aortic valve replacement were treated with rivaroxaban 20 mg once daily (OD) in a prospective cohort study, started on day 3 postoperatively and given for 6 months. The study was registered at ClinicalTrials.gov (#NCT02128841). RESULTS:Ten patients were included (median age, 48; range 39 to 60). Indication was aortic valve stenosis in 6 patients, aortic root aneurysm with severe aortic valve regurgitation in 3 patients, and mixed stenosis/regurgitation in 1 patient. Neither thromboembolic nor bleeding events were observed, and no patient died. Absence of valve thrombosis was demonstrated in all patients. On day 7, median D-dimers were 2723 μg/L (inter-quartile range [IQR] 1672, 5695 μg/L), median TAT levels were 4.5 μg/L (IQR 4.1, 5.6 μg/L); and median peak thrombin generation was 150 nM (IQR 91, 183). On day 90, median D-dimers were 426 μg/L (IQR 278, 569), median TAT levels were 2.7 μg/L (IQR 2.2, 3.1), and median peak thrombin generation were 66 nM (IQR 62, 87). CONCLUSIONS:Rivaroxaban 20 mg OD was safe and effective in a pilot study of 10 low risk patients with mechanical aortic heart valve. Our results justify larger studies investigating the application of anti-Xa inhibitors in patients with mechanical heart valves.
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最新影响因子:10.407 | 期刊ISSN:0049-3848 | CiteScore:2.39 |
出版周期:Monthly | 是否OA:YES | 出版年份:0 |
期刊官方网址:http://www.sciencedirect.com/science/journal/00493848
期刊投稿地址:http://ees.elsevier.com/tr/
自引率:5.90% | 研究方向:医学-外周血管病 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Published twice monthly, the journal serves as a world forum for the rapid dissemination of original research on thrombosis, hemostasis and fibrinolysis. The Editors welcome scientific contributions which give new directions to research in these areas. The journal's policy is to encourage the publication of research, including clinical investigations, which will lead to new approaches in diagnosis, therapy, prognosis and prevention of thrombotic and hemorrhagic diseases. Selected state of the art articles pertaining to thrombosis and hemostasis or other rapidly expanding fields of research are also published. Topics covered include: Cell biology of the cellular components of vessel walls and blood; aggregation and disaggregation of blood cellular elements; molecular biology/genetics of hemostatic factors; structure and function of factors in coagulation and fibrinolysis; activation, polymerizations and gelation of fibrinogen; rheological and other physical properties of blood, thrombi fibrin gels, the different blood vessels and their walls; thrombogenesis; thromboembolization; thrombolysis; epidemiology of thrombosis; atherogenesis. Thrombosis Research now includes Vessels.
该杂志每月出版两次,是一个快速传播血栓形成、止血和纤溶原始研究的世界论坛。编辑们欢迎科学贡献,这些贡献为这些领域的研究提供了新的方向。该杂志的政策是鼓励发表研究,包括临床调查,这将导致在诊断、治疗、预后和预防血栓和出血性疾病的新方法。还出版了与血栓形成和止血或其他快速扩展的研究领域有关的最新文章。课程包括:血管壁和血液细胞成分的细胞生物学;血液细胞成分的聚集和分解;止血因子的分子生物学/遗传学;凝血和纤维蛋白溶解因子的结构和功能;纤维蛋白原的活化、聚合和凝胶化;流变学和其他物理。血液、凝血酶纤维蛋白凝胶、不同血管及其壁的性质;血栓形成;血栓栓塞;溶栓;血栓形成的流行病学;动脉粥样硬化。血栓形成研究现在包括血管。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
HEMATOLOGY (血液学) 3区 PERIPHERAL VASCULAR DISEASE (外周血管病) 3区 |
31/71 30/65 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
199 | 172 | 27 |
引文计数(2018)
文献(2015-2017)
3279次引用
1373篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Hematology
|
#37/120
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研究方向:医药科学 血液系统 红细胞异常
审稿时间: 2个月内
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接受率: 中等(50%命中)
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审稿时间: 2个月内 接受率: 比较困难(25%命中)
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审稿时间: 2个月内 接受率: 一般容易(75%命中)
影响因子:13.029
ISSN:1522-8517
研究方向:医学-临床神经学
影响因子:4.506
ISSN:0167-594X
研究方向:医学-临床神经学
影响因子:7.723
ISSN:2162-402X
研究方向:ONCOLOGYIMMUNOLOGY-IMMUNOLOGY
影响因子:4.912
ISSN:1524-9557
研究方向:医学-免疫学
影响因子:12.02
ISSN:2326-6066
研究方向:ONCOLOGY-IMMUNOLOGY
影响因子:3.698
ISSN:1750-9378
研究方向:ONCOLOGY-IMMUNOLOGY
影响因子:6.63
ISSN:0340-7004
研究方向:医学-免疫学
影响因子:3.077
ISSN:1534-7354
研究方向:医学-全科医学与补充医学
影响因子:0
ISSN:1868-8497
研究方向:ONCOLOGY-ENDOCRINOLOGY & METABOLISM
发表一篇学和医学成像类SCI论文
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