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Abstract:
BACKGROUND:Although cannabis is known to have cardiovascular and psychoactive effects, the implications of its use before surgery are currently unknown. The objective of the present study was to determine whether patients with an active cannabis use disorder have an elevated risk of postoperative complications. METHODS:The authors conducted a retrospective population-based cohort study of patients undergoing elective surgery in the United States using the Nationwide Inpatient Sample from 2006 to 2015. A sample of 4,186,622 inpatients 18 to 65 yr of age presenting for 1 of 11 elective surgeries including total knee replacement, total hip replacement, coronary artery bypass graft, caesarian section, cholecystectomy, colectomy, hysterectomy, breast surgery, hernia repair, laminectomy, and other spine surgeries was selected. The principal exposure was an active cannabis use disorder, as defined by International Classification of Diseases, Ninth Edition, Clinical Modification (ICD-9-CM) diagnostic codes for cannabis dependence and cannabis abuse. The primary outcome was a composite endpoint of in-hospital postoperative myocardial infarction, stroke, sepsis, deep vein thrombosis, pulmonary embolus, acute kidney injury requiring dialysis, respiratory failure, and in-hospital mortality. Secondary outcomes included hospital length of stay, total hospital costs, and the individual components of the composite endpoint. RESULTS:The propensity-score matched-pairs cohort consisted of 27,206 patients. There was no statistically significant difference between patients with (400 of 13,603; 2.9%) and without (415 of 13,603; 3.1%) a reported active cannabis use disorder with regard to the composite perioperative outcome (unadjusted odds ratio = 1.29; 95% CI, 1.17 to 1.42; P < 0.001; Adjusted odds ratio = 0.97; 95% CI, 0.84 to 1.11; P = 0.63). However, the adjusted odds of postoperative myocardial infarction was 1.88 (95% CI, 1.31 to 2.69; P < 0.001) times higher for patients with a reported active cannabis use disorder (89 of 13,603; 0.7%) compared with those without (46 of 13,603; 0.3%) an active cannabis use disorder (unadjusted odds ratio = 2.88; 95% CI, 2.34 to 3.55; P < 0.001). CONCLUSIONS:An active cannabis use disorder is associated with an increased perioperative risk of myocardial infarction.
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最新影响因子:8.986 | 期刊ISSN:0003-3022 | CiteScore:3.08 |
出版周期:Monthly | 是否OA:YES | 出版年份:1940 |
自引率:7.00% | 研究方向:医学-麻醉学 |
出版地区:UNITED STATES |
SCI期刊coverage:Science Citation Index Expanded(科学引文索引扩展)
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Anesthesiology is the official Journal of the American Society of Anesthesiologists. It is widely regarded as the preeminent scientific journal in the specialty.
麻醉学是美国麻醉师协会的官方刊物。它被广泛认为是该专业最杰出的科学期刊。
大类(学科) | 小类(学科) | 学科排名 |
医学 |
ANESTHESIOLOGY (麻醉学) 1区 |
1/31 |
年度总发文量 | 年度论文发表量 | 年度综述发表量 |
165 | 157 | 8 |
引文计数(2018)
文献(2015-2017)
4377次引用
1421篇文献
序号 | 类别 | 排名 | 百分位 |
1 |
大类(学科):Medicine
小类(学科):Anesthesiology and Pain Medicine
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研究方向:医学-精神病学
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研究方向:医学-精神病学
发表一篇学和医学成像类SCI论文
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