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Neurology
影响因子:11.8 DOI:10.1212/WNL.0000000000009405
作者: Vilaplana E,Rodriguez-Vieitez E,Ferreira D,Montal V,Almkvist O,Wall A,Lleó A,Westman E,Graff C,Fortea J,Nordberg A 发表时间:2020-09-10 12:54:08
keywords: Vilaplana ERodriguez-Vieitez EFerreira DMontal VAlmkvist OWall ALleó AWestman EGraff CFortea JNordberg A
关键词:
Abstract
OBJECTIVE:To study the macrostructural and microstructural MRI correlates of brain astrocytosis, measured with 11C-deuterium-L-deprenyl (11C-DED)-PET, in familial autosomal-dominant Alzheimer disease (ADAD). METHODS:The total sample (n = 31) comprised ADAD mutation carriers (n = 10 presymptomatic, 39.2 ± 10.6 years old; n = 3 symptomatic, 55.5 ± 2.0 years old) and noncarriers (n = 18, 44.0 ± 13.7 years old) belonging to families with mutations in either the presenilin-1 or amyloid precursor protein genes. All participants underwent structural and diffusion MRI and neuropsychological assessment, and 20 participants (6 presymptomatic and 3 symptomatic mutation carriers and 11 noncarriers) also underwent 11C-DED-PET. RESULTS:Vertex-wise interaction analyses revealed a differential relationship between carriers and noncarriers in the association between 11C-DED binding and estimated years to onset (EYO) and between cortical mean diffusivity (MD) and EYO. These differences were due to higher 11C-DED binding in presymptomatic carriers, with lower binding in symptomatic carriers compared to noncarriers, and to lower cortical MD in presymptomatic carriers, with higher MD in symptomatic carriers compared to noncarriers. Using a vertex-wise local correlation approach, 11C-DED binding was negatively correlated with cortical MD and positively correlated with cortical thickness. CONCLUSIONS:Our proof-of-concept study is the first to show that microstructural and macrostructural changes can reflect underlying neuroinflammatory mechanisms in early stages of Alzheimer disease (AD). The findings support a role for neuroinflammation in AD pathogenesis, with potential implications for the correct interpretation of neuroimaging biomarkers as surrogate endpoints in clinical trials.
摘 要
期刊介绍
《NEUROLOGY》 (点击进入期刊详情)
英文简介 : As the leading clinical neurology journal worldwide, Neurology is directed to physicians concerned with diseases and conditions of the nervous system. The journal''s purpose is to advance the field by presenting new basic and clinical research with emphasis on knowledge that will influence the way neurology is practiced. The journal is at the forefront in disseminating cutting-edge, peer-reviewed information to the neurology community worldwide.
中文简介 : (来自Google、百度翻译) 作为世界领先的临床神经病学杂志,神经病学是针对医生关心的疾病和条件的神经系统。该杂志的目的是通过介绍新的基础和临床研究,强调将影响神经病学实践方式的知识,推动该领域的发展。该杂志在向全球神经病学社区传播最前沿的、同行评议的信息方面处于领先地位。
CIRCULATION RESEARCH 期刊中科院评价数据
新中科院分区
大类(学科) 小类(学科) 学科排名
医学

CLINICAL NEUROLOGY (临床神经病学)

13/197
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总被引频次 :89258

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