Renal denervation is a new technique approved effective for resistant-hypertension treatment .The common renal denervation system consists of a generator and a flexible catheter .During this minimally invasive procedure , the interventionalist uses a steerable catheter with a radio frequency ( RF) energy electrode tip .The RF energy is delivered to the renal artery via standard femoral artery access .A series of 2-minute ablation are delivered in each renal artery to distroy the nerves system .The procedure does not involve a permanent device implant .By deactivating the renal nerves , and therefore reducing sympathetic nerve transmission , a significant and reliable reduction in blood pressure could be achieved .In this review, potential complications and future sights of renal denervation are also discussed .

Progress on renal sympathetic nerve ablation for refractory hypertension

Hypertension is a chronic cardiovascular disease worldwide.Its association with major adverse cardiac and cerebral events and favorable effects of antihypertensive therapy are ndisputed.It has been estimated that the total number of patients are more than one billion people［1］.In recent years, the drug reatment of hypertension has made great progress, especially for a large number of long-acting antihypertensive drugs and the application of the new compound preparation so that the control rate of hypertension significantly increased.However, hypertensive patients received diuretics, including more than three high-dose antihypertensive drug treatment, but has not yet reached the target blood pressure, clinically known as refractory hypertension (treatment resistant hypertension) about the total number of patients with 20% to 30% ［2］, and such patients have a higher incidence of adverse cardiovascular events［3］.efractory hypertension is not only caused by many reasons, but also illustrates the limitations of the medication.Therefore, people began to say, non-drug treatment of hypertension.Most recently, attention has been redirected to the sympathetic nervous system in the pathogenesis of hypertension.In addition, interruption of the renal sympathetic nervous system in humans with resistant hypertension has been studied with promising results.In 2009, Monash University, Australia Krum professor′s first report of renal sympathetic nerve ablation(Renal sympathetic denervation) was used in the treatment of resistant hypertension, creating a non-drug treatment of essential hypertension in new ways.In this review, a brief introduction mentioned the research progress of this new technology.