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Fibrocytes are bone marrow-derived mesenchymal progenitors that co-express hematopoietic cell antigens and markers ofmonocytic lineage as well as fibro-blast products.During wound healing, fibrocytes have been found to possess the ability of antigen-presentation to naive T cells in the inflammatory phase.Moreover, they can pro-mote the endothelial cell proliferation, migration and angio-genesis by secreting several proteins.Fibrocytes can fur-ther differentiate into mature mesenchymocyte lineage, suchas fibroblasts, myofibroblasts and adipocytes, and they may represent the systemic source of myofibroblasts that exert a contractile force required to close tissue wounds.A deep understanding of the mechanism involved in fibrocyte mi-gration and differentiation may lead to the development of a novel theory of normal physiology and pathology.
