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Objective: To study the active sites of podophyllotoxin derivatives. Methods: Some podophyllotoxin derivatives were analyzed by quantum and mechanics method. Results: Some information was given according to the calculation results about HOMO and LUMO electron density. The C-4 position is the position for effective modification. The B ring and E ring are important active centers. Conclusion: The hole of positive charge in B ring easily combines with an acceptor within the molecular. Some quinolones with similar electronic construction to podophyllotoxin may have antitumor activity.
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耐药结核病的药物治疗及研究进展
近年来,耐药结核病的流行越来越严重,全球范围内的耐药结核病对各国的公共卫生已构成了严重威胁,各国的专家学者都在关注耐药结核病的产生原因,并开展大量的研究遏制耐药结核病的发展.本文检索并分析了关于耐药结核病产生以及治疗药物的相关报道,对耐药结核病的发生机制,诊断方法以及新的治疗药物报道进行了综述.
