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Recently, we have demonstrated the ability of naringin, a well-known flavanone glycoside of grapefruits and citrus fruits, to prevent neurodegeneration in a neurotoxin model of Parkinson’s disease. Intraperitoneal injection of naringin protected the nigrostriatal dopaminergic projection by increasing glial cell line-derived neurotrophic factor expression and decreasing the level of tumor necrosis factor-alpha in dopaminergic neurons and microglia, respectively. These results suggest that naringin can impart to the adult dopaminergic neurons the ability to produce glial cell line-derived neurotrophic factor against Parkinson’s disease with anti-inlfammatory effects. Based on these results, we would like to describe an important perspective on its possibility as a therapeutic agent for Parkinson’s disease.
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复方青骨凝胶中柚皮素的HPLC测定
复方青骨凝胶是在治疗腰腿痛的有效中药汤剂验方的基础上,以青风藤、骨碎补、大黄、四方木皮、杜仲等19味中药配伍,并以卡波姆为辅料制成的、具有缓释作用的新型复方中药外用凝胶剂,对风湿、类风湿引起的关节痛疗效确切[1].方中骨碎补为该制剂抗炎的主药之一.
