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Diabetic retinopathy is a leading cause of acquired blindness, and it is the most common ischemic disorder of the retina. Available treatments are not very effective. Efforts to inhibit diabetic reti-nopathy have focused either on highly speciifc therapeutic approaches for pharmacologic targets or using genetic approaches to change expression of certain enzymes. However, it might be wise to choose innovative treatment modalities that act by multiple potential mechanisms. The resis-tance to ischemic injury, or ischemic tolerance, can be transiently induced by prior exposure to a non-injurious preconditioning stimulus. A complete functional and histologic protection against retinal ischemic damage can be achieved by previous preconditioning with non-damaging isch-emia. In this review, we will discuss evidence that supports that ischemic conditioning could help avert the dreaded consequences that results from retinal diabetic damage.
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高压氧预处理诱导兔脊髓缺血耐受现象产生
INTRODUCTION Paraplegia is a severe complication of desendingthoracic aneurysm (TA) and thora coabdominal anerysm(TAA) repair[1]. This complication is caused by spin al cord ischemia secondary to aortic clamping. Many methods and drugs have been suggeste d to protect against ischemic spinal cord injury[2-4] but the efficacy is still under dispute. Therefore, it is necessary to find some effective methods or dru gs to effectively protect against spinal cord ischemic injury.
