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神经生长因子和碱性成纤维细胞生长因子联用治疗坐骨神经损伤实验研究
AIM:To explore the co- effect of nerve growth factor (NGF) and basic fibroblast growth factor (bFGF) on the sciatic nerve after injury. METHODS: 96 rats were divided into normal saline group, NGF group, bFGF group and NGF+ bFGF group. Sciatic nerve function index (SFI), nerve conduction velocity, regeneration axon counting were detected in the 3 rd, 6 th, 9 th, 12 th week postinjury. RESULTS:The end of SFI, nerve conduction velocity, regeneration axon counting in NGF+ bFGF group were higher than those in the other groups. CONCLUSION:The co- effect of NGF and bFGF on sciatic nerve is better than the effect of NGF or bFGF alone.