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钙拮抗剂对缺血性脑损伤后Bcl-2和Bax基因表达的作用
AIM: In order to explore whether the member of Bcl-2 gene family, for example, Bcl-2 and Baa, are induced after cerebral ischemia, and whether expression of genes can be modulated by calcium-antagonist. METHODS: The rat cerebraliachemic models were made by Nagasawa and Zea Longa improvement method, by occluding left middle cerebral artery; the expression of Bcl-2 and Baa mRNA were measured by RT-PCR method. RESULTS: After administration of nimodipine, Bcl-2 mRNA was up-regulated in the hippocampus at 6 and 24 h alter ischemia, while Bax mRNA was down-regulated at 6 and 24h after ischemia. CONCLUSION: Calcium-antagonist can up-regulate Bcl-2 mRNA and down-regulate Baa mRNA. Increasing the ratio of Bcl-2 and Bax mRNA may contribute to the anti-apoptic effect of nimodipine.
