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体重减轻对肝脏中游离脂肪酸摄取和肝胰岛素抵抗的影响
肥胖通常与肝脏中脂肪积聚有关,而肝脏脂肪又与全身及肝脏局部的胰岛素抵抗有关.低热卡饮食可改善脂肪肝,增加胰岛素敏感性.
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脂肪乳剂在小儿手术与创伤后应用的代谢研究
本文对28例1个月~12岁手术或创伤后患儿一次性输入脂肪乳剂,与30例对照组比较,两组间血甘油三酯、游离脂肪酸峰值、8小时后恢复值均无统计学差异(P>0.05),血胆固醇无明显变化(P>0.05).提示小儿手术与创伤后高分解代谢期,脂肪乳剂可正常代谢和利用.
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We aimed to clarify the effects of troglitazone to prevent the development of fatty liver in Otsuka Long-Evans Tokushima fatty (OLETF) rats, an obese type2 diabetes model. Treatment of 0.2% troglitazone for 16 weeks significantly decreased blood glucose, serum insulin and free fatty acid (FFA) concentration (P<0.05 for each) in the OLETF rats leaving their food intake, body weight and general fat pad weight unaffected compared with those of their lean littermates, Long-Evans Tokushima Otsuka (LETO) rats. Troglitazone restored increase in liver weight and hepatic triglyceride(TG) content of the OLETF rats (P<0.05 for each). These findings were accertained by histological examination which showed that fat deposition, necrosis and vacuolization of hepatocyte, markers for fatty liver, were diminished by troglitazone treatment. Messenger RNA expression of microsomal triglyceride transfer protein in the liver, a marker for hepatic TG output, was not significantly different between OLETF and LETO rats with or without troglitazone treatment. Fatty acid composition such as C18∶1(oleic acid) showed no remarkable change after troglitazone treatment in OLETF rats, indicating no dietary influence to hepatic lipogenesis. These indicate that reduction in circulating FFA level may be one of the main mechanisms for troglitazone to prevent the development of insulin resistance and fatty liver.