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注射用呋苄西林钠中主要杂质的结构推测
呋苄西林(又名呋脲苄青霉素,furbenicillin)为一种广谱的半合成青霉素衍生物.临床上常用其钠盐和钾盐的注射用制剂,对大肠杆菌、绿脓杆菌、奇异变形杆菌等作用较强,可用于治疗由上述细菌引起的败血病、尿路感染、肺部感染、软组织感染和肝胆系统感染等~([1,2]),其结构式见图1.该药仅在我国上市,目前国内企业生产销售的主要是呋苄西林钠(furbenicillin sodium,1)和注射用1.
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The quantitative estimation of amikacin (AMK) in AMK sulfate injection samples is reported using FTIR-derivative spectrometric method in a continuous flow system. Fourier transform of mid-IR spectra were recorded without any sample pretreatment. A good linear calibration (r40.999, %RSDo 2.0) in the range of 7.7-77.0 mg/mL was found. The results showed a good correlation with the manufacturer's and overall they all fell within acceptable limits of most pharmacopoeial monographs on AMK sulfate.