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一阶导数紫外分光光度法测定瑞巴派特片中瑞巴派特的含量
OBJECTIVE: To establish a method for the assay of Rebamipide tablets by the first orderderivative spectrophtometry. METHODS: A phosphate buffer (pH6.8) was selected for solvent. The distance D between the derivative peak at 219± 1nm and valley at 230±1nm of the first order derivative spectrum obtained by scanning from 270 to 200nm was ased as the quantitative basis. The assay was calculated through comparing the peak-valley distance of sample with the standard. RESULTS: There was a good linear relationship between Rebamipide concentration in the range of 1.1～8.5 μg/ml and the peakvalley distance of derivative spectrum with r=0.9999 The average recovery was 99.5% with RSD of 0.3% (n=6). CONCLUSIONS: The method is simple, rapid, accurate and reproducible for the determination of Rebamipide.
