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多环芳烃接触者P21蛋白跟踪研究
Polycyclic Aromatic Hydrocarbons(PAHs),first determined as a sort of chemical carcinogen, can exist in chemical substance such as coal tar pitch (CTP) and coke oven volatiles (COV). The carcinogenesis of PAHs has been confirmed by epidemiological studies among high risk population and animal experiments. The excessive mortality of lung cancer has been found in workers exposed to CTP and COV. Lung cancer can be induced in rats or mice with CTP by inspiring CTP fog or intratracheal instillations. The latest advance in the study of molecular biology has been applied to the fields of occupational cancer prevention and diagnosis. The study of the amount, effect, and injury of carcinogen with biomarkers has become one of the imporant methods for the early detection for occupational lung cancer.
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CK20、Ki67、Ras P21蛋白在腺性膀胱炎和膀胱腺癌中的表达及意义
目的通过分析正常膀胱黏膜,腺性膀胱炎(cystitis glandularis, CG)和膀胱腺癌（adenocarcinomaof bladder）中CK20、Ki67、Ras P21蛋白三种肿瘤标志物的表达,探讨它们之间发生、发展的关系，提高对CG和膀胱腺癌的认识。方法采用免疫组化法,测定正常膀胱粘膜10例、腺性膀胱炎及膀胱腺癌组织各60例石蜡切片中的CK20、Ki67、Ras P21蛋白的表达情况。结果①正常膀胱粘膜、腺性膀胱炎及膀胱腺癌组织中CK20、Ki67、Ras P21的阳性表达分别为0/10，21/60(35.00%)，33/60(55.00%)；0/10，16/60(26.67%)，35/60（58.33%)；0/10，17/60(28.33%)，22/60(36.67%)；组间差异有统计学意义(<0.05)，CK20、Ki67、Ras P21阳性表达依次递增。结论①腺性膀胱炎可能是正常膀胱粘膜发展成膀胱腺癌的一个中间阶段；②CK20、Ki67、Ras P21蛋白是腺性膀胱炎向膀胱腺癌转变的良好指标，为诊断早期膀胱腺癌提供信息；③CK20、Ki67、Ras P21免疫组化阳性的腺性膀胱炎，临床治疗尤其注意随访。
