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Liquid biopsies in cancer
Liquid biopsy, the detection of biomarkers from body fluids, has been widely used on circulating tumor cells ( CTCs) , circulating tumor DNA (ctDNA), circulating tumor microRNA, exosomes and other kinds of molecular characterization. Cancer, a series of comprehensive mechanisms, presents in different molec-ular forms that could be used in clinic for diagnosis, treatment, drug monitoring and prognosis judgement via liquid biopsies. Liq-uid biopsies are available to tumor heterogeneity, resistance, pro-gression and metastases in clinic. Technologies for detection and analysis was improving for the obvious limitation of liquid biop-sies, that leads the future directions. In this review, we provided critical views of liquid biopsies on cancer, including different methods of liquid biopsies and applications of liquid biopsies in current clinical trials and practice.
