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The effect of U50488, a selective k-opioid receptor agonist, on cardiac rhythm in the isolated perfused rat heart and intracellular calcium ([Ca2+] i) in the single ventricular myocyte were studied. The results showed that U50488 can induce arrhythmias dose-dependently in the isolated perfused rat heart and increase [Ca2+] i in the single ventricular myocyte. The effect of U50488 can be blocked by a selectivek-receptor antagonist, nor-binaltorphimine.The arrhythmogenic effects and the increase of [ Ca2 + ] i induced by U50488 were blocked by U73122, neomycin and streptomycin, which are selective phospolipase C inhibitors, but not by U73433, the inactive structural analog of U73122. These results demonstrated that the arrhythmogenic effect of cardiac k-receptor is due to activation of phosphoinositol/Ca2+ pathway.
相关标签
- glycogen synthase kinase-3 inhibitor
- adventitial-derived relaxing factor
- calcium-dependent potassium (KCa) channel
- adenosine triphosphate-dependent potassium (KATP) channel
- endothelial nitric oxide synthase
- cardiac myofibroblast
- Vascular endothelial growth factor Myocardial infarction
- k-opioid
- Isolated
- Phospholipase
