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Objective: To explore the curative effect of integrated traditional Chinese and western medicinal (TCM-WM) therapy on incipient diabetic nephropathy (DN).Methods: One hundred patients with incipient DN were randomly divided into two groups, the treated group (50 cases) was treated with TCM-WM therapy, which was carried out by using Jiangtang Jianshenling (JTJSL) capsule, a Chinese preparation for supplementing Qi and nourishing Yin, on the basis of effectively controlling blood glucose with western medicine. The 50 patients in the control group were treated with western medicine alone. The course of treatment was three months. Changes of symptoms, signs and related laboratory parameters were observed before and after treatment.Results: The total effective rate in the treated group was 90% while that in the control group 58%, the difference between the two groups was significant (P<0.05). The related parameters including 24 hrs urinary albumin excretion, blood sugar, microalbuminuria, blood and urine β2-microglobulin, blood lipids and hemorrheologic parameters were all improved after treatment in the treated group (P<0.05 or P<0.01).Conclusion: The curative effect of TCM-WM was better than that of western medicine alone in treating incipient DN.
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维生素C和E联合治疗对伴有尿白蛋白排泄率增高的Ⅱ型糖尿病患者的肾脏保护作用
背景和目的尿白蛋白排泄率(AER)水平升高预示发展为终末期肾疾病的高危险性.对链尿霉素诱发的糖尿病予以维生素C或E可减轻白蛋白尿和肾小球肥大.我们试以药理学剂量下维生素C和E来检验其是否能降低伴有高AER的Ⅱ型糖尿病患者的AER.
