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AIM To study the change of T cell subsets and erythrocytes immune function in children with acuterotavicus enteritis (RE) and to explore its clinical significance.METHODS T cell subsets were detected by indirect immunofluorescence technique, RBC immune functionwas achieved by detecting RBC C3b receptor rosette (RBC-CR1R) and RBC immune complex rosette (RBC-ICR). The statistical significance of differences was evaluated by using analysis of variance (ANOVA).RESULTS The percentage rate of CD3 and CD4 cell and the ratio of CD4/CD8 in acute stage of RE weresignificantly lower than those of control ( P <0.01), while the percentage rate of CD8 cell remained almostunchangec Along with the improvement of clinical symptoms, the level of CD3, CD4 and CD4/CD8returned to normal in recovery stage. RBC-CR1R in acute stage of RE was significantly lower than that ofcontrol (F = 15.44, P<0.01) and returned to normal in recovery stage. RBC-ICR rose slightly in acute stageof RE, but there was no significant difference between acute stage of RE and the control (F=0.02518,P>0.05). Correlative analysis showed that RBC-CR1R was positively correlated to the percentage rate ofCD4 cell (r =0.528l, P<0.01) and the ratio of CD4/CD8 (r=0.4832, P<0.01), in acute stage of RE.CONCLUSION Cellular immune might take part in the development of RE, CD4/CD8 ratio might berelated to the prognosis of RE. The immune function of RBC reduced secondarily in acute stage of RE. It isnecessary to keep the immune function of RBC in treatment of RE in order to strengthen the patient's abilityof anti-infection.
