INTRODUCTION The essence of Moist Exposed Burn Therapy (MEBT) is to keep burn wound in a physiological moist environment to promote the discharge and removal of necrotic tissues, and the repair and regeneration of the wound. This is what MEBT is distinguished from dry exposed therapy and other conventional treating therapies. Therefore, the basic requirement of the topical medicine, Moist Exposed Burn Ointment (MEBO), specially designed for and used in MEBT, is the ability of maintaining wound moisture without affecting good drainage. MATERIALS AND METHODS 42 healthy adult rabbits of both sexes, females without pregnancy, weighing 2.1～ 3.0 kg were used in this study. Animals were depilated on back by applying 8 ％ sodium sulfide solution. Anesthesia was achieved by intraperitoneal injection of pentobarbital sodium (40 mg/kg). On each side of the back, one deep second degree burn wound was formed by igniting for 4 seconds, with a 100(C heated cake of copper, 3 cm in diameter. The depth of wound was verified by pathological examination. MEBO Ointment was supplied by Beijing Guangming Chinese Medicine Institute for Burns, Wounds and Ulcers. Vaseline for medicinal use was produced by Yangzizhou Pharmaceutical Factory of Nanchang City of China. Model EPIC evaporometer (Servomed) was used for measuring wound evaporation. Experiment 1. MEBO treatment with auto－ control: Ten rabbits were used in this experiment. The water evaporation value of normal skin was measured before injury. Then the animal was burned on both sides of the back. Wound on one side was treated with MEBO, while wound on the other side was allowed to dry spontaneously as auto－ control. MEBO was applied to a thickness of 0.5 mm to 1 mm and renewed at an interval of 6 to 8 hours. Measurement of wound water evaporation was done at 0.5, 6, 24, 48, 72 and 168 hours postburn. The healing time of each wound was recorded. Experiment 2. MEBO treatment with dry exposed therapy control: Twenty－ four rabbits were randomly divided into 2 groups, MEBO treatment group and dry exposed therapy group, 12 in each. The treatment method and observations were the same as described in Experiment 1. Pathological examinations were con ducted at the same time. Experiment 3. Vaseline treatment: Eight rabbits with deep second degree burn wounds on both sides of the back were treated with Vaseline. The treatment method and observations were the same as described in Experiment 1. The results were compared with MEBO treating group. The ambient temperature was 25－ 28(C and humidity 50± 5 ％ . The data were presented as mean value± and analyzed statistically using t－ test. RESULTS Wound water evaporation: Compared with normal skin, the water evaporation values of burn wounds treated with dry exposed therapy in both experiments 1 and 2 increased dramatically and reached their peaks at 6 hours post injury, and then tended to decrease slowly. Compared with the values of dry exposed therapy, the water evaporation of wound treated with MEBO decreased significantly (PGross observation:

常温真空药品干燥机开发和应用

1 概述在药品干燥中感棘手的品种要数呈粘性和热敏性的中药浸膏、阿胶、明胶,以及热敏温度更低的介于冷冻干燥和常规干燥温度低限以下20～60℃的产品,如许多抗菌素、核黄素和酶制剂等生物制品.