Acute ischemic stroke has become a major disease burden with high mortality and morbidity rates. There is a lack of evidence-based medicine conifrming the efifcacy of common treatments. Panax notoginseng saponins, the main active ingredient of radix notoginseng, have a neuro-protective role in ischemic brain injury, and have been popularized as a maintenance treatment for acute cerebral infarction and its sequelae. We conducted literature searches on the Web of Science, ClinicalTrials.gov, Cochrane Collaboration, CNKI, Wanfang and the China Scientific&Technological Achievements Database and analyzed the experimental and clinical outcomes of studies investigating the use of radix notoginseng in the treatment of ischemic brain injury to improve the understanding of relevant research trends and existing problems. We found that over the past 10 years, China has maintained its interest in Panax notoginseng research, while such studies are scarce on the Web of Science. However, Chinese researchers often focus on the neuroprotective role of radix notoginseng in ischemic brain injury, but there are no large-scale clinical data to conifrm its efifcacy and safety. There remains a need for more rigorous large-sam-ple randomized controlled clinical trials with long-term follow-up, to determine whether radix notoginseng lowers stroke recurrence and improves patient’s quality of life.

开发自动判断酸碱失衡类型的计算机软件及应用

目的 开发一种快速、准确判断酸碱平衡紊乱类型的软件,以指导临床处理酸碱紊乱.方法 以改良Henderson-Hasselbalch公式以及代偿预计值计算公式为基础建立数学模型,用Visual Basic6.0编写全部程序.输入动脉血气及血清电解质检测数据即可输出酸碱平衡的类型.结果 ①使用本软件判断与手工计算相比,对单纯性酸碱失衡和双重性酸碱失衡能达到95%符合.对三重性酸碱失衡达到85%符合,经kappa检验,k=0.95,u=10.72>u0.01=2.276,故P<0.01,可以认为这两种计算方法结果之间的一致性具有统计学意义,且根据参考判断指标k值,其一致性强度为极强;②与酸碱图相比,对单纯性酸碱失衡能达到88.89%符合.对双重性酸碱失衡达到99.45%符合,经kappa检验,k=0.8477,u=10.025>u0.01=2.276,故P<0.01,可以认为这两种方法结果之间的一致性具有统计学意义,且根据参考判断指标k值,其一致性强度为强.结论 我们自主开发程序,使用方法简单、准确性高,可作为临床诊断和治疗的参考,值得临床使用.

碱性成纤维细胞生长因子对缺血再灌注损伤大鼠血脑屏障通透性的研究

目的:探讨脑缺血再灌流损伤大鼠血脑屏障是否对碱性成纤维细胞生长因子(bFGF)通透.方法:采用大脑中动脉腔内阻塞模型,股静脉滴注[125I]-bFGF,对大脑冠状冰冻切片进行放射自显影,图象分析测定光密度.结果:放射自显影结果显示模型鼠缺血病灶侧影像较健侧及正常鼠浓集.光密度测定结果显示模型鼠病灶侧与其健侧及正常鼠同侧的吸光度值差异显著(P＜0.05;P＜0.05).结论:[125I]-bFGF经股静脉滴注后,能通过脑缺血再灌流损伤大鼠血脑屏障浓集于缺血脑区.