Interleukin-18 gene promoter polymorphisms are potential risk factors for ischemic cerebrovascular disease, and the-607C al ele may increase ischemic stroke risk in the Han Chinese population. In the present study, we recruited 291 patients with ischemic cerebrovascular disease from the Affi-liated Hospital of Qingdao University Medical Col ege, China, and 226 healthy controls. Both pa-tients and controls were from the Han population in northern China. Immunoresonance scattering assays detected increased serum amyloid A protein, C-reactive protein, and interleukin-18 levels in ischemic cerebrovascular disease patients compared with healthy controls. Analysis of the-607C/A (rs1946518) polymorphism in the interleukin-18 gene promoter showed ischemic cerebrovascular disease patients exhibited increased frequencies of the CC genotype and C al eles than healthy controls. Genotype and al ele frequencies of the interleukin-18-137G/C (rs187238) polymorphism and the-13T/C (rs11024595) polymorphism in the 5'-flanking region of serum amyloid A, showed no significant difference between the two groups. Multivariate logistic regression analysis on the interleukin-18 promoter A/C genetic locus, for correction of age, gender, history of smoking, hyper-tension, diabetes mel itus, hypercholesteremia, and an ischemic stroke family history, showed ischemic cerebrovascular disease risk in individuals without the A al ele (C homozygotes) was 2.2-fold greater than in A al ele carriers. Overal , our findings suggest that the-13T/C (rs11024595) polymorphism in the 5′-flanking region of serum amyloid A has no correlation with ischemic cere-brovascular disease, but the C al ele of the-607C/A (rs1946518) polymorphism in the interleukin-18 promoter is a high-risk factor for ischemic cerebrovascular disease in the Han population of northern China. In addition, the A al ele is likely a protective gene for ischemic cerebrovascular disease.

目的：探讨血清中白细胞介素-6(IL-6)水平与宫内节育器(IUD)存在的关系。方法：采用酶联免疫吸附试验测定64例置器妇女(试验组，试验组又分为置器出血组和无出血组)，以及60例健康妇女(对照组)血清中IL-6水平，同时测定两组血清中C-反应蛋白(CRP)水平。结果：试验组64例中有31例血中IL-6水平升高，与对照组相比差异显著(P＜0．001)。但其中置器出血组与不出血组中IL-6水平无统计学差异(P＞0．05)。试验组及对照组血清中CRP检验结果均为阴性。结论：宫内节育器引起子宫内膜无菌性炎症反应，导致部分妇女血清中IL-6水平升高。IL-6可能在宫内节育器的避孕机理中起重要作用。

Several studies have reported that C-reactive protein (CRP), an inlfammation biomarker, may be associated with the prognosis of prostate cancer (PCa). The objective of this systematic review is to summarize the predictive role of CRP for survival in PCa as reported in previous studies. Related studies were identiifed, and evaluated for quality through multiple search strategies. Data was collected from studies comparing overall and cancer-speciifc survival (CSS) in patients with elevated CRP levels and those having lower levels. However, for progression-free survival (PFS), data were collected according to the log of CRP. The hazard ratio (HR) and its 95% conifdence interval (CI) were used to assess the strength of associations. A total of nine studies (n= 1,497) were evaluated in this meta-analysis (ifve for overall survival (OS), four for CSS and two for PFS). For OS and PFS, the pooled HR of CRP was statistically signiifcant at 1.51 (95%CI, 1.28-1.79) and 1.50 (95%CI, 1.25-1.81), respectively. For CSS, the pooled HR was 1.91 (95%CI, 1.36-2.69) with higher CRP expression in PCa, which strongly indicates poorer survival in PCa. This study demonstrates that CRP may have a critical prognostic value in patients with prostatic cancer.