肾上腺素β受体和胆碱能M受体对边缘细胞钾离子转运的调控

耳蜗血管纹边缘细胞向内淋巴转运钾离子对耳蜗内淋巴的生成,电化学特征的维持起到直接作用.钾离子经边缘细胞转运的过程除了受细胞内外离子浓度、膜电压的调控外还受细胞膜受体及细胞内信号转导系统调节.目前研究发现肾上腺素β受体促进边缘细胞的钾离子转运;胆碱能M受体则抑制边缘细胞的钾离子转运.肾上腺素β受体和胆碱能M受体对边缘细胞钾离子转运的调控作用具有重要的临床意义.

Methods In the present study, 69 male patients with essential hypertension at different stages were compared with a group of age-matched normotensivecontrols. β-adrenoreceptor maximum bound volume (Bmax) in pedpheml lymphocytes was measured by 3H-dihydroalprenolol(3 H-DHA) radio ligand binding.β-adrenoreoeptor responsiveness was determined by Salbutamol(injection).Results In patients with essential hypertension at stages Ⅰ and Ⅱ, Bmax was significantly higher (P＜0.01 and P＜0.001, respectively) and the chronotropic doses of Salbutamol reqaired to increase the heart rate by 30 beats/min (CD30) were significantly lower(P＜0.01 and P＜0.001,respectively) than in age-matched normotensive control subjects.In patients with essential hypertension at stage Ⅲ, Bmax was significantly lower and CD30 was significantly higher (both P＜0.01) than those in the age-matched normotensive control subjects.Bmax was significantly higher and CD30 was significantly lower (both P＜0.001) in patients with essential hypertension and with left ventricular hypertrophy (LVH) than that in patients with essential hypertension but without LVH. In patients with essential hypertension and heart failure, Bmax was significantly lower and CD30 was significantly higher (both P＜0.001) than those in patients with essential hypertension without heart failure.Conclusions The changes of β-adrenoreceptor density and function were related to hypertension,hypertension complicated with ventricular hypertrophy,and heart failure. They may be viewed as indexes of the condition in the patients with essential hypertension.