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Objective. To investigate the difference of rejection in single versus combined pancreas and kidney transplantation in rats.Methods. All ograft models including simultaneous pancreas and kidney(SPK)transplant and pancreas or kidney transplant alone were established in SD-Wistar rats, rejections of pancreas and kidney in different models were compared morphologically and functionally.Results. Mean survival time (MST)of pancreas was significantly prolonged in SPK than in pancreas transplant alone(PTA)( 11.5 days vs. 9.2 days, P ＜ 0.05). Incidence of interstitial pancreatic rejection at grade Ⅱ and grade Ⅲ was much obvious in PTA than in SPK(42.9% vs. 12.5% at grade Ⅱ and 28.6% vs 6.3% at grade Ⅲ , P ＜0.05). No significant difference was found in MST between SPK and kidney transplant alone(KTA). Administration of cyclosporine A prolonged the MS T of pancreas and kidney, without altering the tendency stated above.Conclusions. In SPK, the function of pancreas is protected by kidney hence the severity of rejection is reduced, whereas the function of kidney is not protected by pancreas. It suggests that different organs differ in immunoallergization and immunoregula tion, and immune response tend to attack organs with greater immunoactivity, those organs with minor one could be protected. Cyclosporine A is effective on prolonging the MST of pancreas and kidney.
