首页 > 文献资料
-
重复电针预处理对兔脊髓缺血再灌注损伤的保护作用
AIM:To investigate whether pretreatment with repeated electroacupuncture(EA) could induce ischemic tolerance against transient spinal cord ischemia in rabbits.METHODS: 24 male New Zealand white rabbits were randomly assigned to 3 groups(n=8 each),animals in the control group received no treatment; animals in the SP and EA group received sodium pentobarbitone 30 mg/kg each day for 5 days; animals in EA group were also received electroacupuncture at the Zusanli acupoint 30 min a day for 5 days.24 hours after the last treatment,spinal cord ischemia was induced by an infrarenal aortic occlusion for 20 min.Hind limb motor function was determined with the Tarlov criteria at 4,8,12,24 and 48 h after reperfusion.All animals were sacrificed at 48h after reperfusion and the spinal cords(L5) were removed immediately for histopathologic study.RESULTS:The neurologic outcome and histopathology(48 h) in the EA group were significantly better than the control group(P=0.006).CONCLUSION: Pre ischemic treatment with electroacupuncture significantly reduces spinal cord ischemia reperfusion injury in rabbits.
