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化学品安全数据单（续3）
本期论文涉及化学品包括苯的氨基或硝基化合物、铅等。现选取苯胺、铅两种化学物，进一步对其安全数据单做一简单介绍。本部分所有毒性相关数据均来自2005版《有毒物质数据库》(Hazardous Substances Data Bank， HSDB）或《化学物质毒性效应登记数据库》(Registry of Toxic Effects of Chemical Substances，RTECS)。危险性分类参照2011版《全球化学品统一分类和标签制度》（Globally Harmonized System of Classification and Labeling of Chemicals，GHS），分类信息仅做参考。
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INTRODUCTION The “ischemic tolerance in brain” fou nded by Kitagawa et al[1] is an ideal model to investigate the mechanisms of cerebral ischemic damage and neuroprotection. But exposing patients to brief ischemic events before an antici pated cerebral ischemia occurs seems difficult and unacceptable in clinical practice. Therefore, some investigators studied the possibility of chemical preconditionin g which mimics ischemic preconditioning, and demonstrated that some chemicals coul d induce the ischemic tolerance in brain [2]. However, the clinical applic ation of these chemical substances is yet to be elucidated because of their toxicity or side ef fects. Recently, isoflurane and sevoflurane have been proved to be able to mimic ischemic preconditioning in myocardial ischemia[3-6]. Whether they could also induce the same effects in brain has not been reported yet. Therefore, the present stud y was undertaken to testify if isoflurane could induce ischemic tolerance in brain on middle cerebral artery occlusion (MCAO) rat model.
