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异基因造血干细胞移植前后应用地西他滨治疗骨髓增生异常综合征转化的急性髓系白血病——1例治疗经验及文献复习
Acute myeloid leukemia (AML) transformed by myelodysplastic syndrome (MDS) has low complete remission,high risk of relapse,short survival time and poor prognosis.If the patients also with FLT3-ITD positive,the outcome will be worse,and the possibility of survival is very low,even after allogeneic hematopoietic stem cell transplantation (Allo-HSCT).In this paper a 44 year old female patient with FLT3-ITD+ AML-M5,transformed by MDS treated in our department were reported.The patient received chemotherapy with decitabine before and unrelated donor Allo-HSCT,and maintenance therapy of small dose of decitabine after HSCT.The early relapse after transplantation was successfully controlled,and the life of the patient had been over 2 years.
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FLT3-ITD阳性急性早幼粒细胞白血病并发肺部真菌感染一例并文献复习
目的:初步探讨联合索拉菲尼治疗全血细胞减少的FLT3-ITD阳性急性早幼粒细胞白血病患者的安全性和有效性,提高分子靶向治疗认识.方法:报道一例FLT3/ITD阳性急性早幼粒细胞白血病合并肺真菌感染的临床症状,实验室特征,应用抗真菌药物及索拉菲尼联合化疗的过程.结果:FLT3/ITD阳性患者首次化疗缓解率与阴性患者无差别,应用索拉菲尼巩固治疗药物耐受性好,过程顺利.结论:FLT3-ITD阳性的急性早幼粒细胞白血病患者早期缓解率与阴性患者无明显差异,序贯索拉菲尼巩固治疗安全有效.
关键词: 急性早幼粒细胞白血病 FLT3-ITD阳性 索拉菲尼