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T大颗粒淋巴细胞白血病并中枢神经系统血管炎1例及文献复习
We detected monoclonal T lymphocyte by TCRβ variable region genes in a patient with T large granular lymphocytic leukemia combined with central nervous system vasculitis.We also detected bone marrow cytology,cerebrospinal fluid cytology and flow cytometry,brain histopathology and imaging in the patient,in order to explore clinical features,pathogenesis,diagnosis,therapy and prognosis of T-large granular lymphocytic leukemia combined with central nervous system vasculitis.After treated with cyclophosphamide and dexamethasone in combination with intrathecal chemotherapy,cranial MRI showed placeholder lesions significantly narrowed.The patient returned to normal neurologic status.T-large granular lymphocytic leukemia may combine with central nervous system vasculitis,and early diagnosis and treatment can improve the curative effect.
