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依托医院计算机网络开展信息服务的做法及体会
知识经济时代,医院信息服务的意义不再是对资料被动的收集、整理、保管、统计,而是以现代信息服务为核心,为医院的医疗管理、医疗活动及技术人员、病员、社会提供多功能、多层次的信息服务.我院自1998年运行医院信息管理系统(HIS)后,医院的管理水平迈上了一个新台阶.HIS系统中所具有的综合查询系统无疑为科室领导、管理部门及院领导提供了可靠的医疗数据,成为院领导不可缺少的决策依据,但这些功能远不能满足各类人员的需要.在运行好HIS的基础上,我们充分发挥网络功能开展信息服务,满足了不同人员的需要,取得了较好的效果.
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Osteocytes, the most abundant bone cells, form an interconnected network in the lacunar-canalicular pore system (LCS) buried within the mineralized matrix, which allows osteocytes to obtain nutrients from the blood supply, sense external mechanical signals, and communicate among themselves and with other cells on bone surfaces. In this study, we examined key features of the LCS network including the topological parameter and the detailed structure of individual connections and their variations in cortical and cancellous compartments, at different ages, and in two disease conditions with altered mechanosensing (perlecan deficiency and diabetes). LCS network showed both topological stability, in terms of conservation of connectivity among osteocyte lacunae (similar to the‘‘nodes’’ in a computer network), and considerable variability the pericellular annular fluid gap surrounding lacunae and canaliculi (similar to the‘‘bandwidth’’ of individual links in a computer network). Age, in the range of our study (15–32 weeks), affected only the pericellular fluid annulus in cortical bone but not in cancellous bone. Diabetes impacted the spacing of the lacunae, while the perlecan deficiency had a profound influence on the pericellular fluid annulus. The LCS network features play important roles in osteocyte signaling and regulation of bone growth and adaptation.
