首页 > 文献资料
-
高效抗病毒治疗促使艾滋病患者免疫功能重建
The characteristics of AIDS is that HIV infection induces CD4 + T cell defects that includes a quantitave CD4 + T cells depletion and a loss of T helper cells function leading to a progressive immune deficiency. Early report indicated that this immune deficiency was irreversible, even with the antiretroviral therapies. More recently, however, clinical benifits of hightly active antiretroviral therapies (HAART) are increasingly evidenced by resolving opportunistic infections and malignancies, as well as declining hospitalization and mortality rates. This suggests that potent and sustained suppression of viral replication, at least to some extent, is associated with reconstitution of the immune system even in adult patients treated at advanced stages of the disease. Such immune reconstitution which was demonstrated firstly by a French reseach group includes (the group leader is Pr Brigitte Autran)(1) a rapid rise in CD4 + and CD8+ T cells followed by a slower CD4 + T cell increase; (2) a rapid rise in memory CD4 + T cells during the first three months of treatment by late increase in naive T cells coexpressing CD45RA and CD62L molecules after 3 months of efficient antiviral treatment;(3) a significant reduction of CD4 and CD8 activation markers in parallel to plasma virus load reduction;(4) a restoration in CD4 + T cell reactivity to recall antigens. These observations open new perspectives for the understanding of CD4 + T cells deficiency and therapeutic strategies of HIV infection. In the present review we will address some of the questions raised by immune restoration with HAART when administered at advanced stages of the disease.
-
资源有限地区HIV/AIDS疾病进展监测及抗病毒治疗疗效评价的替代指标
外周血CD4+T淋巴细胞计数和血浆病毒载量是监测HIV/AIDS疾病进展及评价高效抗逆转录病毒治疗(HAART)疗效的两项关键指标.目前公认的主流检测手段包括:经流式细胞术检测CD4+T淋巴细胞计数,采用实时荧光定量PCR技术分析血浆HIV RNA.这两种方法均要求专门仪器及配套试剂,价格昂贵,对操作者要求也较高,难以在资源有限地区广泛应用.因此,寻找适合我国国情的技术简便、费用相对低廉、结果可靠的替代指标具有重要的现实意义.
