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虽然慢性胰腺炎的病理已经十分清楚,但其早期的致病机制尚不明确.慢性胰腺炎的一般特点为纤维化,慢性炎症和胰腺实质的消失,这些特征会随着疾病的发展而逐渐出现,同时还伴有急性胰腺炎的症状.一些专家认为慢性胰腺炎继发于急性胰腺炎.另一些则认为慢性胰腺炎首先发生,急性胰腺炎则在此基础上发生.慢性胰腺炎所引起的疼痛可通过许多机制发生.增高的胰腺压力可干扰神经,影响血流,改变pH值,并引起有毒物质的潴留,激活动作电位.组织的破坏和炎症介质的释放可刺激传入神经.甚至,炎症可直接破坏神经,引起神经性疼痛.掌握疼痛在外周和中枢神经系统中的神经冲动传递路径才能找出减轻胰性疼痛的有效方法.疼痛可以通过内脏、迷走、脊神经和膈神经等外周神经传递.它也可通过脊髓的背侧神经束和脊髓丘脑束中继传递.因此寻找到新的治疗胰性疼痛的方法是可能的.
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Long gap peripheral nerve injuries usually reulting in life-changing problems for patients. Skeletal muscle derived-multipotent stem cells (Sk-MSCs) can differentiate into Schwann and perineurial/endoneurial cells, vascular relating pericytes, and endothelial and smooth muscle cells in the damaged peripheral nerve niche. Application of the Sk-MSCs in the bridging conduit for repairing long nerve gap injury resulted favorable axonal regeneration, which showing supe-rior effects than gold standard therapy--healthy nerve autograft. This means that it does not need to sacriifce of healthy nerves or loss of related functions for repairing peripheral nerve injury.
