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Object. The effects of ATP-introduced a rise in cytosolic free Ca2 + concentration and inhibition of nitric oxide were investigated.Method. Measurement of f ree Ca2+ ([Ca2+ ]i)of cultured rat tail arterial smooth muscle cells using Fura-2/AM dual excitation wavelength spoctrofluorometer.Results. There are two components of [ Ca2 + ]i can be evoked by ATP. One part is Ca2 + ertry from Ca2 + channel and formed a plateau. The another part is a peak that released f rom Ca2 + store. Both of them can be inhibited by NO.Conclusion. The ATP induced [ Ga2 + ]i rise that release Ca2 + from both InsP3 and ryanochine receptors and Ga2 + entry through calcium channels. The inhibition of NO on ATP induced [ Ca2 + ]i rise that was mediated by cGMP.
关键词： NO ATP free Ca2 + Ca2 + store
