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单胺氧化酶基因多态性与帕金森病的关系
单胺氧化酶(MAO)是一种膜结合蛋白,在多巴胺氧化代谢中起重要的作用.MAO基因定位于染色体Xp11.23,不同MAO酶活发表的个体对特定神经递质代谢速度可能不同,它们对相关疾病的发生可能有不同的易感性.由于MAO在多巴胺代谢和神经毒性物质MPTP代谢方面起重要作用.因此,MAO的遗传多态性可能是帕金森病(PD)发病的易感性因素之一.
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呆聪液对老年痴呆大鼠血清酶及LPO的影响
Objective To explore the effect of Daicong solution (DCS) on aged rats dementia model.Method The experiment used 22 month old rats whose basal nuclei was destroyed by bilateral electrolytic method as model for aged rats dementia.They were treated with DCS for a month.Then the level of superoxide dismutase (SOD),lipid peroxide(LPO),monoamine oxidase (MAO) and cholinesterase(CHE) in the serum was measured. Result Compared with the control,the activity of SOD increased markedly(P< 0.01), the content of LOP and activity MAO and CHE were decreased(P< 0.01).Conclusion DCS is effective in treating the aged dementia.