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BACKGROUND:?Vitamin?D?is?a?fat-soluble?sterol?derivative?that?is?predominantly?synthesized?in?the?liver?and?has?multiple?functions.?The?accumulative?data?showed?that?the?clinical?manifestations?and?prognosis?of?chronic?liver?diseases?are?associated?with?serum?vitamin?D?levels. DATA?SOURCES:?A?PubMed?and?Google?Scholar?search?using?terms:?"vitamin?D",?"25(OH)D",?"liver?disease",?"viral?hepatitis",?"non-alcoholic?fatty?liver?disease",?"liver?ifbrosis",?"cirrhosis",?"hepatocellular? carcinoma"? and? "autoimmune? liver? disease"?was? performed,? and? relevant? articles? published? in? English?between?January?2000?and?March?2014?were?reviewed.?Full-text?publications?relevant?to?the?ifeld?were?selected?and?relevant?articles?from?reference?lists?were?also?included.?RESULTS:?The? insufifciency? or? deifciency? of? vitamin? D? is?common?in?various?kinds?of?chronic?liver?diseases?including?viral?hepatitis?B?and?C.?Serum?25-hydroxyvitamin?D?and?vitamin?D?receptors?are?possibly?interrelated?with?the?incidence,?treatment?and?prognosis?of?diseases.?Though?the?evidence?of?vitamin?D?supplementation?in?viral?hepatitis?and?associated?liver?diseases?is?still?limited,?there?is?great?potential?to?apply?this?adjuvant?therapy?to?improve?the?treatments.?CONCLUSIONS:?Although? the? exact? role? and? mechanisms?of?vitamin?D?have?not?been?fully?elucidated?in?chronic?liver?diseases,?it?is?potentially?beneifcial?in?the?treatment?of?chronic?liver? diseases.? Further? mechanistic? studies? are? needed? to?validate?its?clinical?application.
