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中药提取物物理性质评价与改性技术研究的探索
中药制剂的原料大部分是中药提取物,其理化性质不明确,往往流动性差,吸湿性强,稳定性差.对于这些物料所表现出的共性和特殊性问题很少进行系统深入的评价与研究,因而也缺少改善其不良物理性质方法(改性技术)的研究.结合我们自己的研究工作,综述了中药提取物物理性质的评价方法和改性技术,为解决中药制剂的研究和生产中存在的问题,为中药由传统制剂向现代制剂向现代剂型转变提供研究思路.
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中药粉体改性技术的研究进展
中药粉体大多表现出流动性差、吸湿性强、黏性大、润湿性差等不良物理性质,影响中药制剂的生产过程甚至疗效.准确表征中药粉体的物理性质并改变其不良特性成为提高中药制剂质量及推动中药现代化进程的关键.该文综述了中药粉体物理性质的评价方法和改性技术,为解决中药制剂研究和生产过程中存在的问题提供了思路和借鉴,从而实现中药制剂的质量控制标准化和剂型现代化.
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骨科内植物表面细胞生物反应与纳米化改性
钛合金内植物具有良好的生物相容性,然而,其界面骨整合效果并不理想,易导致内植物松动和脱落.传统的内植物界面改性技术,包括机械方法(如切削、磨刻、抛光、爆喷等)、化学方法(如酸蚀、碱蚀等)和生物涂层方法,并未从根本上解决植入界面骨整合不足的问题[1].
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中药粉体改性技术与改性设备研究进展
中药粉体因其复杂的理化性质,导致流动性差、吸湿性强、黏性大、易团聚等.近年来,国内外药剂学工作者借鉴材料、化工、化药等领域的粉体改性技术,用于改善中药粉体理化性质取得了一定进展.本文总结了中药粉体改性技术与改性设备,提出了中药粉体改性的基本思路与发展前景.
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中国血管腔内外科技术发展历程20年介入物理疗法的激光技术、血管腔内支架发展技术、支架材料学改性技术、提高术后患者的生活质量
The endovascular surgery in China has been developing from none to a few, from a few to many, from primary to refinement,from blind to directional, and it is expecting to grow even rapidly as "spring bamboo after a timely rain" in which "science is the first motive force" and a consistent diligence and endeavor putting into it from vascular scientists and practitioners has been playing a distinctively important role. It has experienced a hard initiation and developing process. Describing here is mainly the development of endolumianl vascular surgery for major vein and artery, i.e., the vena cava and the aorta, however it was still from research and practice of the medium-sized vessels. Until now, we have treated more than 137 cases. The total number of patients with aortic dissection treated by endografting should be more than 1 000. The endoluminal treatment, including the hybrid or semi-interventional method for treating aortic dissection is very likely to have a particularly better future in comparison to the treatment for those with the infra-renal abdominal aortic aneurysm in which requires, unlikely the surgery for handling aortic dissections with long segmental involvement of the aorta,less surgical demanding. It is predicted that the distinctively difference we have had now between China and the Western World in term of the incidence of abdominal aortic aneurysm and aortic dissections and their related treatment would be gradually disappeared in the future. The endoluminal treatment for treating greater vessel disorders has less mortality and postoperative complications, such as hyperplagia, stoke or cerebral deficits, paralysis,etc., less rehabilitation is required and thus has a fruitful future.
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中药浸膏粉体吸湿及改性技术研究进展
中药浸膏粉体通常吸湿性强,对中药制剂的成型影响较大,是长期困扰中药药剂生产的难题.本文通过文献研究,结合研究工作实践,分析中药浸膏粉体吸湿的过程与吸湿机制,以及相关影响因素,寻求改善中药浸膏粉体吸湿性的合理方法.
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中药提取物表面物理改性技术探索
自国家提出"中药现代化产业行动"计划以来,中药的提取、分离、浓缩等制药过程的前处理工艺已逐步迈入了生产控制智能化和生产过程管道化、系统化.如:水提取采用多功能强制循环流水线、醇提取采用改进型动态提取以及引进国外先进的连续气动式间歇出渣和分离技术,在单机设备上采用自控,生产线采用计算机集成控制等,以确保中药复方提取物生产过程处于稳定和可控状态.
