Objective:The present study was designed to test the hypothesis that inflammation is involved in the end-organ damage(EOD) induced by sinoaortic denervation(SAD) in rats.Method:SAD was performed in male Sprague-Dawley rats at the age of 10 weeks.Under anaesthesia,aortic nerves were cut and the sinus region of the carotid artery was stripped and painted with 10% phenol.Pathological evaluation of EOD and the determination of plasma or tissue levels of the factors related to inflammation,including thromboxane B2(TXB2) interleukin-1(IL-1),tumour necrosis factor α(TNF-α) and reactive oxygen species(ROS) were performed at 16 weeks after SAD.Pathological evaluation of EOD included heart weigh ratio,myocardial and blood vessel hydroxyproline and collagen volume fraction,glomerular injury score and number of infiltrating inflammatory cells.Indomethacin(20 mg/kg per day,orally) or vitamin E(100 mg/kg per day,orally) was administered for 12 weeks,beginning from4 weeks after SAD,to observe their effects on SAD-induced EOD.Results:There were significant fibrosis and inflammatory infiltration in the myocardium and blood vessels,represented by higher hydroxyproline and collagen volume fraction,and a large amount of inflammatory cells in the tissues of SAD rats.Heart weight and kidney glomerular injury score were significantly higher in ed significantly after SAD.Indomethacin and vitamin E significantly decreased the contents of some factors related to inflammation in SAD rats.Both drugs also alleviated myocardial and vessel fibrosis,inflammatory infiltration and kidney damage.Conclusion:Inflammation is involved in the organ damage induced by SAD in rats.

亲毛囊性蕈样肉芽肿伴嗜酸粒细胞增多一例

患者男，69岁。3年来，头、躯干和四肢出现散在红斑、毛囊性丘疹及痤疮样皮损(如粟丘疹、囊肿等)和脱发，病程中伴外周血嗜酸粒细胞增多。皮损组织病理检查示真皮内灶性慢性炎细胞浸润伴毛细血管增生，毛囊周围慢性炎细胞浸润伴血管增生，伴少许嗜酸粒细胞，考虑为毛囊炎，予抗组胺药和抗生素治疗后皮损炎症消退，瘙痒减轻。3个月后，枕部出现斑块伴脱发，组织病理检查示真皮内密集淋巴样细胞、嗜酸粒细胞浸润，毛囊周围大量淋巴样细胞浸润伴较多嗜酸粒细胞，可见不典型淋巴细胞，部分侵入毛囊，毛囊上皮黏液样变性。阿新蓝染色阳性。免疫组化染色：CD20、CD79a、EB病毒(EBV)、CD56、磷酸葡萄糖变位酶-1(PGM-1)、髓过氧化物酶(MPO)、CD7、抗角蛋白单克隆抗体AE1/AE3均阴性，异形细胞CD3、CD4、CD5、CD2、CD43、泛素羧基末端水解酶-L1 (UCHL-1)均阳性。T细胞受体基因重排结果为阴性。诊断：亲毛囊性蕈样肉芽肿。予光化学疗法(PUVA)联合阿维A治疗，仍有新发皮损，目前患者在随访中。