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心房颤动:我们到底知道多少?
目前对心房颤动(房颤)的研究已经在各个层面展开,从基因到通道蛋白、从细胞器到大体解剖、从电生理到组织结构、从入心大静脉到心房特殊结构、从心房神经节丛到各种体液因子的影响、从药物治疗到非药物治疗,各个领域都有一批学者在执着地深入研究.
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Rho-associated protein kinase is an essential regulator of cytoskeletal dynamics during the process of neurite extension. However, whether Rho kinase regulates microtubule remodeling or the distri-bution of adhesive proteins to mediate neurite outgrowth remains unclear. By specifical y modulat-ing Rho kinase activity with pharmacological agents, we studied the morpho-dynamics of neurite outgrowth. We found that lysophosphatidic acid, an activator of Rho kinase, inhibited neurite out-growth, which could be reversed by Y-27632, an inhibitor of Rho kinase. Meanwhile, reorganization of microtubules was noticed during these processes, as indicated by their significant changes in the soma and growth cone. In addition, exposure to lysophosphatidic acid led to a decreased brane distribution of vinculin, a focal adhesion protein in neurons, whereas Y-27632 recruited culin to the membrane. Taken together, our data suggest that Rho kinase regulates rat hippocampal neurite growth and microtubule formation via a mechanism associated with the redistribution of vinculin.
