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间充质干细胞促进慢性创面血管新生的机制及应用
间充质干细胞（MSC）由于具有自我更新、多向分化及旁分泌功能，被看作是留存在成人体内的胚胎干细胞。MSC 能够在组织损伤所致的趋化因子刺激下迁移到损伤基底部分化成血管内皮细胞或周皮细胞、旁分泌多种促血管生成的细胞因子如血管内皮生长因子和转化生长因子β等促进创面血管新生及细胞外基质重建，为局部创面的修复创造良好微环境，加速糖尿病溃疡、大面积烧伤等所致慢性创面的愈合。因此，本文主要就 MSC 促进血管新生在创面修复方面的作用及机制做一综述。
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间充质干细胞治疗吸入性损伤的实验研究进展
Inhalation injury seriously threatens the survival and quality of life in burn and trauma patients.So far there is no breakthrough in the treatment of inhalation injury.A significant advance has been witnessed in the experimental study of the use of stem cells in the treatment of lung injury in recent years.In this paper,according to the results of our study in the systemic transplantation of bone marrow mesenchymal stem cells for the treatment of inhalation injury,the effect of mesenchymal stem cells on anti-inflammatory process and repair of lung tissues in inhalation injury,and its possible mechanisms are reviewed.
