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To study the killing effect of suicide gene CD on mouse gastric cancer. Methods: CD gene was transduced with the retroviral vector. The killing effect and bystander effect of CD gene on mouse gastric cancer cell line MFC were observed. The mouse gastric cancer model was used for in vivo study. The CD gene containing virus was injected into the tumors. The volumes of the tumors in every group were measured in time. Results: Significant killing effect and bystander effect were observed by CD gene in vitro, 70~80% cell death resulting from 20% of CD gene transduction. In vivo, CD/5-Fc caused tumor to diminution. Conclusion: CD/5-Fc system has significant killing effect on mouse gastric cancer
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高建青教授课题组在构建基于干细胞的新型生物类靶向传递系统的应用研究上取得新突破
2015年5月8日,浙江大学药学院药物制剂研究所高建青教授课题组在国际控释学会会刊《控释杂志》( Journal of Controlled Release)在线发表了题为“Synergistic effects of co-administration of suicide gene expressing mesenchymal stem cells and prodrug-encapsulated liposome on aggressive lung melanoma metastases in mice”的研究论文( http://www.sciencedirect . com/science/article/pii/S0168365915003053)。该研究利用骨髓间充质干细胞的肿瘤归巢性质构建了具有生物活性的细胞载体传递系统,并联合脂质纳米载体进行共给药,实现了药物-基因的共靶向传递,并在小鼠恶性肺黑色素转移瘤模型上取得了良好的抑瘤效果。
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自杀基因联合细胞因子的癌症治疗
INTRODUCTIONThe transfer of suicide genes into tumor cells is currently being used in a variety of clinical gene therapy trials for the treatment of cancer, and suicide gene therapy is the transduction of a gene that transforms a non-toxic into a toxic substance[1].