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Temporal lobe epilepsy is associated with astrogliosis. Notch1 signaling can induce astrogliosis in glioma. However, it remains unknown whether Notch1 signaling is involved in the pathogenesis of epilepsy. This study investigated the presence of Notch1, hairy and enhancer of split-1, and glial fibrillary acidic protein in the temporal neocortex and hippocampus of lithium-pilocar-pine-treated rats. The presence of Notch1 and hairy and enhancer of split-1 was also explored in brain tissues of patients with intractable temporal lobe epilepsy. Quantitative electroencephalo-gram analysis and behavioral observations were used as auxiliary measures. Results revealed that the presence of Notch1, hairy and enhancer of split-1, and glial ifbrillary acidic protein were en-hanced in status epilepticus and vehicle-treated spontaneous recurrent seizures rats, but remain unchanged in the following groups:control, absence of either status epilepticus or spontaneous recurrent seizures, and zileuton-treated spontaneous recurrent seizures. Compared with patient control cases, the presences of Notch1 and hairy and enhancer of split-1 were upregulated in the temporal neocortex of patients with intractable temporal lobe epilepsy. Therefore, these results suggest that Notch1 signaling may play an important role in the onset of temporal lobe epilepsy via astrogliosis. Furthermore, zileuton may be a potential therapeutic strategy for temporal lobe epilepsy by blocking Notch1 signaling.
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颞叶癫(癎)海马硬化的影像学诊断
内侧颞叶结构,尤其海马和杏仁核,在人类的学习、记忆、情感等[1-3]方面起重要作用,且与某些神经精神疾病如癫癎、精神分裂症、阿尔茨海默症[4-6]等有重要关系.内侧颞叶癫(癎)(MTLE)属局灶性癫(癎).
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颞叶癫痫患者记忆损害的研究
Objective: This paper reviewed recent resear ch on memory impairments in temporal lobe epilepsy patients, including clinical features of spatial, ver bal, visual and semantic memory disorders, as well as their mechanisms and clini cal significance.
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双侧颞叶癫痫的诊断及治疗探讨
颞叶癫痫(temporal lobe epilepsy, TLE)是顽固性癫痫中常见的类型。目前普遍开展的是一侧 TLE 的手术治疗,治疗效果早已得到广泛的认同,而对于双侧颞叶癫痫(bilateral temporal lobe epilepsy, BTLE)的诊治研究尚处于探索阶段。由于术后无癫痫发作率及癫痫缓解率低及严重的记忆功能损害,通常认为BTLE 不适合手术,长期以来手术治疗BTLE 受到很大的限制。本文就 BTLE 的诊治进行探讨。
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颞叶内侧癫痫记忆损害的功能磁共振研究进展
癫痫是神经科仅次于脑血管病的第2位高发疾病,其中约70%的病例可用药物治愈或控制,其余为难治性癫痫,其中以颞叶内侧癫痫为常见,后者是近年难治性癫痫的研究热点.