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In the present study, we investigated the effects of hypothyroidism on the morphology of astrocytes and microglia in the hippocampus of Zucker diabetic fatty rats and Zucker lean control rats. To in-duce hypothyroidism, Zucker lean control and Zucker diabetic fatty rats at 7 weeks of age oral y received the vehicle or methimazole, an anti-thyroid drug, treatment for 5 weeks and were sacrificed at 12 weeks of age in al groups for blood chemistry and immunohistochemical staining. In the methimazole-treated Zucker lean control and Zucker diabetic fatty rats, the serum circulating tri odothyronine (T3) and thyroxine (T4) levels were significantly decreased compared to levels ob-served in the vehicle-treated Zucker lean control or Zucker diabetic fatty rats. This reduction was more prominent in the methimazole-treated Zucker diabetic fatty group. Glial fibril ary acidic protein immunoreactive astrocytes and ionized calcium-binding adapter molecule 1 (Iba-1)-immunoreactive microglia in the Zucker lean control and Zucker diabetic fatty group were diffusely detected in the hippocampal CA1 region and dentate gyrus. There were no significant differences in the glial fibril ary acidic protein and Iba-1 immunoreactivity in the CA1 region and dentate gyrus between Zucker lean control and Zucker diabetic fatty groups. However, in the methimazole-treated Zucker lean control and Zucker diabetic fatty groups, the processes of glial fibril ary acidic protein immunoreactive astrocytes and Iba-1 immunoreactive microglia, were significantly decreased in both the CA1 region and dentate gyrus compared to that in the vehicle-treated Zucker lean control and Zucker diabetic fatty groups. These results suggest that diabetes has no effect on the mor-phology of astrocytes and microglia and that hypothyroidism during the onset of diabetes promi-nently reduces the processes of astrocytes and microglia.
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siRNA SOCS1 transfection in cancerogenesis of experimental model with altered thyroid function
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Histopathological changes in rat liver in hyper-and hypothyroidism are associated with DNA methyltransferase activity
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江门市2005-2010年先天性甲状腺功能减低症筛查状况分析
目的:对2005-2010年江门市甲状腺功能减低症筛查工作开展状况进行统计分析.方法:用荧光酶免疫分析法测定TSH筛查可疑新生儿并召回复查TSH及FT4、FT3诊断先天性甲状腺功能减低症.结果:6年共筛查新生儿158169例,确诊甲状腺功能减低症患儿66例,平均发病率41.73/10万,年发病率呈不规则变化趋势;2010年筛查覆盖率达87.99%,阳性召回率达96.3%;失访率31.8%,主要失访原因为患儿家长对先天性甲状腺功能减低症的危害及治疗预后欠缺充分认识.结论:我市甲状腺筛查工作开展模式取得较大成效,全地区筛查覆盖率和阳性召回率获得迅速提高;加强甲状腺功能减低症相关的围产期保健工作有可能明显降低甲状腺功能减低症的发病率;加强CH家长与大龄患儿的健康教育,是提升其诊疗依从性及治疗预后的必要措施.