Objective To investigate the influences of previous angina pectoris on coronary collateral circulation and left ventricular function in patients with acute myocardial infarction. Methods 307 patients with a first episode acute myocardial infarction underwent selective coronary angiography and left ventriculography. The relation of previous angina pectoris to coronary collateral circulation, peak creatine kinase and left ventricular function were analyzed.Results ① In the 307 patients, there were 192(62.5 % ) with previous angina [PA ( + ) group] and 115 (37.5 % ) without [PA ( - ) group]. ②The peak creatine kinase (CK) and CK- MB were significantly higher in PA (-) group than in PA (+) group ( P ＜ 0.05 for both comparisons) . ③ Collateral circulation to infarct- related artery was more likely to be present in PA (+) group than in PA (-) group ( P ＜ 0.05) . ④ The left ventricular ejection fraction was significantly increased, and the left ventricular wall motion Cortina score decreased, in PA ( + ) group than in PA ( - ) group ( P ＜ 0.01 for both comparisons) .Conclusion In patients with acute myocardial infarction, previous angina pectoris may have beneficial effects on coronary collateral circulation and left ventricular unction.

Objective To study the differences in blood pressure (BP)levels and the main factors raising BP among the population in Guangdong province.Methods The data analyzed stem from the sampling survey of hypertension in Guangdong Province in 1991,covering 42,894 subjects over 15 years old.Individual characteristics included age,sex,occupation education,smoking,alcohol drinking and body mass indx(BMI).Results Systolic and diastolic BP increased with age.The hypertension prevalence rate in male is higher than in female.The age-adjusted prevalence rate in office personnel is the highest(12.9%)among all occupations.It was increased with educfation level and BMI (in people educated atuniversity and over is 13.1%),and higher in smokers and alcohol-drinkers than non -smokers and nonalcohol-drinkers.Conclusions Age,occupation,education,smoking,alcohol drinking and BMI all effect BP.These risk factors should be reduced in the Guangdong population.

Objective To analyze the relationship between polymorphism at the Apolipoprotein AI (Apo AI) gene and the risk for coronary artery disease. Methods A total of 107 patients (mean age 56 ± 11 years) diagnosed as having stable angina pectoris (SAP) (23 cases), unstable angina pectoris (UAP)(23 cases) or myocardial infarction (MI) (61 cases)were prospectively evaluated. DNA was obtained from the 107 patients and 50 controls. In order to determine the Apo AI genotypes at two polymorphic sites (G/A at -75 bp, and C/T at +83 bp), DNA was PCR amplified and digested with MspI. Results The frequency of carriers of the rare allele at the - 75 bp site (M1-) was 0.49 in cases and 0.30 in controls ( P＜ 0.05). The frequencies of the M 1 - allele among patients with SAP, UAP, MI and controls were 0. 37 (vs. Controls, P ＞ 0.05), 0. 54 (vs. Controls, P ＜0.05), 0.52 (vs. Controls, P＜ 0.05) and 0.30, respectively. The frequencies for carriers of the rare allele at the + 83bp polymorphism (M2) were observed among patients with SAP (0.09, vs. Controls, P ＞0.05), UAP (0. 11, vs. Controls, P ＞ 0.05) or MI (0.12, vs. Controls, P ＞ 0.05) and controls (0. 12).There was an slightly increase in the frequency of the M1 - allele in patients with SAP to UAP or MI (0.37vs. 0.54 vs. 0.52; all P ＞ 0.05) and M1 polymorphism as a risk factor for CAD (OR=3.74, P ＜0.05). In the + 83bp polymorphism there was no difference in the allelelic frequencies in cases and controls (0. 11 vs. 0. 12; P ＞ 0.05). There was no significant difference in the frequency of the M2- allele in patients with SAP to UAP or MI (0.09 vs. 0.11 vs.0. 12; all P ＞ 0. 05) and M2 polymorphism not as a factor for CAD ( OR = 0. 80, P ＞ 0. 05) Plasma lipoprotein values in patients with the allele M1 - and M2 - had no different levels than those homozygous for the M1+ andM2+ (P＞ 0.05). Conclusion M1polymorphism (M1 - ) may be as a risk factor for CAD and M2 polymorphism (M2 - ) not as a factor for CAD in Chinese Xinjiang Uygur and Han population.

Objective To study the changes of baroreflex sensitivity (BRS) during head -up tilt test (HUT) in patients with vasovagal syncope (VS),and to examine the relationship between baroreflex sensitivity and neurohormonal factors. Furthermore, to investigate the effects of the changes of BRS on VS.Methods Forty- two patients with unexplained syncope (Among the 42 patients, there were 22 patients with positive HUT and 20 patients with negative HUT respectively) and 20 healthy volunteers (with negative HUT) underwent passive head-up tilt testing, Antecubital vein blood samples were taken before and after HUT, or at syncope. The fasting plasma endothelin ,serum nitric oxide (NO), serum NE were measured. The BRS was assessed on the basis of the linear regression slope the RR interval versus systolic arterial blood pressure during the increment in blood pressure after intravenous administration of phenylephrine. Results ( 1 )During the syncope, the BRS significantly reduced in HUT( + ) group than baseline. At the end of tilt, the level of plasma ET, serum NO in patients with positive HUT significantly increased compared with baseline or normal controls, and the plasma concentration of NE also had the trend of increase. ( 2 ) By multiple regression analysis, a significant negative correlation was found between baroreceptor sensitivity and the plasma ET, NO at the end of HUT in patients with positive HUT, but there was no relationship between BRS and NE. Conclusions During the syncope occure, the BRS in patients with VS decreased significantly compared with normal controls. The abnormal plasma ET, NO concentration might contribute to the mechanism of VS.

Objective The coronary anatomic feature and development after thrombolysis in acute myocardial infarction (AMI) were studied.Mehtods 100 patients with AMI received urokinase and strepokinase. Coronary angiography (CAG) was performed at 90 minuts and again at 3 to 4 weeks.Results Successful thrombolysis occurred in 60 cases,but failed in 40. The ratio of reperfusion was 60％.CAG showed there were residual thrombi in 84 patients (84％) and complete coronary occlusion in 40(40％ ).Angiography at 3 to 4 weeks after thrombolysis showed the stenosis worsened in 8 patients and improved in 10.Conclusion AMI is caused by sudden coronary thrombotic occlusion and can be repeffused by using thrombolytic agent or mechanical methods. Thrombolytic agents usually can not resolve thrombi completely. So percutaneous transluminal coronary angiography (PTCA) is recommended as an important method to improve serious residual stenosis.

Objective Forty cases of IAMI were examined with coronary angiography in order to study the relationship of the vessels with the ECG of IAMI. Methods For coronary angiography Judkin' s method was used; IAMI was diagnosed by the 1979WHO's standard of ISHD and ECG was separately measured by two doctors. Results Most of IAMI with polybranch coronary or its collateral disease (32.5％and 42.5％ ) and only 10 cases (25％) with single branch coronary disease, whose ECGs were untypical.Conclusion IAMI with single-branch coronary disease might express as mild symptoms and have no typical ECG change. While typical ECG change emerges, the coronary artery always showed poly-branch disease or collateral branch obstruction and the disease would be advanced. It is important to pay more attention to the cases of IAMI without classic ECG change so as to give diagnosis and treatment them in time.

Objective To further improve the rate of reperfusion of infarction related artery in AMI, remove the stricture, rescue ischemic myocardiurn, protect cardiac function and ameliorate the longterm prognosis. Method Among 73 patients with AMI, 50 underwent direct PTCA, 15 immediate PTCA,8 rescue PTCA and 20 braces were implanted. Result The proportion of recanalization is 94.5％ (69/73) .The grade of blood flow (TIMI) improved to grade 3 in 20 patients with brace implantation, while 44 to grade 3 and 5 to grade 2 among 49 patients with simple PTCA. Residualstenosis in vessel was 1.8 ± 5.9(-10-10)％ in patients with brace implantation versus 15.4 ± 11. (0 -30)％ with simple PICA. The incidence of reperfusive cardiac arrythmia was 18.1％(10/62). There was mainly frequent ventricular premature beat and short paroxysmal ventricular tachycardia, if left anterior decending branch was reopened,while bradycardia and atrial ventricular block usually occurred after right coronary reperfused. Conclusion Emergency PTCA and brace implantation can apparently improve the proportion of reperfusioa of IRA in AMI. It is necessary to popularize and apply these treatment in medical units with available conditions.

Heart rate variaty (HRV) of 85 cases with AMI was observed in the early phase after onset and rehabilitation phase at first month and sixth month, and was contrasted with six time threshold indices of 111 cases with coronary heart disease and that of 35 normal control. We found the HRV of AMI was apperantly lower in the acute phase than that of coronary heart disease and normal controls. HRV recovered gradually with inclining to be stable after half a year, but it was still lower than that of controls. Low HRV in early phase of AMI suggested the poor prognosis.

In 1985 the International Natural Medicine Society declared the Hoten area, Xinjiang (a province of China) as one of the areas of most pronounced longevity in the world. Why are there more elderly people in Hoten? There are many factors. On the basis of our many years of research, our claim is that diet is the most important factor. Now I will discuss the following factors to illustrate.

Ojbective To find the independent predictors for restenosis after coronary stenting.Methods Quantitative angiography was performed on 60 cases (67 successfully dilated lesions) after angioplasty over 6-months follow-up, and both univariate and multivariate logistic regression analysis were done to identify the correlations of restenosis with clinical factors. Results The total restenosis rate was 31.3％(21 of 67 lesions), and according to univariate analysis the patients who underwent coronary stenting ≥3.5mm had a lower rate of restenosis ( P ＜ 0. 01).Collateral circulation to the obstruction site, high maximal inflation pressure, smoking and the less minimal lumen diameter after PTCA made the rate of restenosis higherower ( P ＜ 0.05) . Multivariate logistic regression analysis showed that coronary stenting ≥ 3.5mm had a low rate of restenosis, but high maximal inflation pressure and smoking made the restenosis rate higher. Conclusion Coronary stent size, maximal inflation pressure and. smoking were independent predictors for restenosis.