Fascin蛋白在肺癌患者血清中的表达及临床意义

目的：探讨Fascin蛋白在肺癌患者血清中的表达及临床意义。方法检测61例肺癌患者及20例肺部良性病变患者血清中Fascin蛋白阳性表达率。结果 NSCLC患者血清中Fascin阳性率(37．25%)明显高于SCLC(7．69%)患者及肺部良性病变患者(5%)；在不同临床分期的NSCLC患者中,Fascin阳性率差异有统计学意义。结论 Fascin在NSCLC患者中表达提高,且与分期相关,有一定判断预后的价值。

Objective:D2 lymphadenectomy has been increasingly regarded as standard surgical procedure for advanced gastric cancer (GC), while necessity No.14v lymph node dissection for distal GC is still controversial. Methods: A total of 920 distal GC patients receiving at least D1+ (D1+7, 8a, 9) or D2 lymph node dissection in our center were enrolled in this study, of whom, 243 patients also had the No.14v lymph node dissected. Other 677 patients without No.14v lymph node dissection were used for comparison.Results:Forty-five (18.5%) patients had No.14v lymph node metastasis. There was no significant difference in overall survival (OS) rate between patients with and without No.14v lymph node dissection. Following stratiifed analysis, in TNM stages I, II, IIIa and IV, No.14v lymph node dissection did not affect OS. In multivariate analysis, No.14v lymph node dissection was found to be an independent prognostic factor in patients with TNM stage IIIb/IIIc GC (HR =0.670, 95% CI, 0.506~0.886, P=0.005).Conclusion:Adding No.14v lymph node to D2 lymphadenectomy may be associated improved OS for middle and lower GC staged TNM IIIb/IIIc.

Objective:Immunoglobin G (IgG) molecules are not only produced by differential B lymphocytes but also expressed in numerous epithelial cancer cells. hTey play important roles in promoting tumor cell growth and survival. However, their expression and function in gastric cancer remains unkown, this study was designed to investigate IgG expression and function in gastric cancer.Methods: IgG expression was evaluated by immunohistochemistry.The relationship between IgG expression and clinicopathological features and clinical outcomes were statistically analyzed. Results:Statistical analyses showed that IgG expression was more frequently detected in patients with cardiac cancer, intestinal type and no lymph node metastasis. Moreover, IgG expression was significantly related to the overall survivalin patients with tumor TNM stages I-III.Multivariate Cox regression analyses revealed that IgG expression was an independent prognostic factor in patients with tumor TNM stages I-III for OS.Conclusion:Our findings demonstrate that IgG was related to gastric cancer progression, and its expression can serve as a novel prognostic biomarker in gastric cancer patients.