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C-反应蛋白:炎性标记物抑或是动脉粥样硬化血栓形成的参与者
C-reactive protein (CRP) was traditionally considered a biomarker of inflammation,however,recent studies have proved that CRP exerts prothrombotic effects on vascular cells and plays a critical role in atherothrombosis.CRP increases the risk of ischemic vascular events,for example,myocardial infarction.CRP has been detected in atherosclerotic lesions in human coronary arteries [1-5].Although CRP has been argued to be involved in the development of atherosclerotic plaque size [6-8],it is surely correlated with activating the blood coagulation system and increasing the risk of thrombosis.The present review focuses on the pivotal role of CRP in trigger of atherosclerosis,stimulation of prothrombetic factor and activation of platelets as well as subsequent development of atherothrombosis.A better understanding of each step involved in this complex process might lead to a new therapeutic strategy to manage patients with CRP-linked atherothrombosis.
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氧化应激与白癜风
白癜风病因复杂,尚未明确.目前学术界关于其发病机制的讨论大致有两派观点:一方认为白癜风是一种原发性的自身免疫性疾病,另一方认为它本质上是一个氧化应激相关的皮肤病[1].本综述旨在从氧化应激这一方面回顾、总结白癜风发病机制的新研究及相关的治疗进展.