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Batroxobin,the thrombin-like enzyme,is used for therapeutic defibrination. We have found that batroxobin has good therapeutic effect in ischemic reperfusion rats and clinical practices in vivo. But we have not studied the neuroprotective effect of batroxobin on anoxic hippocampal neurons in vitro. The purpose of this study was to obtain further information on the mechanism of the batroxobin-induced neuroprotection and examine the neuroprotective effect on neurons exposed to anoxia. The effect of batroxobin on anoxic damages in cultured hippocampal neurons of neonatal rats was investigated by using morphological changes and heat shock protein 70Kd (Hsp70) immunoreactive expression as indicators. The results indicate that batroxobin, besides its defibrination, may have a direct neuroprotective effect on anoxic damage of hippocampal neurons.
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人工髋关节置换术的现状与热点
人工髋关节置换术近年来在许多方面都取得了长足的进展,也出现了一些备受关注的热点问题。在髋关节负重界面方面,高交联聚乙烯材料的改进使得陶瓷对高交联聚乙烯成为具有表现优异的负重面组合,陶瓷对陶瓷界面的碎裂风险随着新型复合陶瓷的出现也得到了大限度的降低,成为年轻患者负重界面的优选方案。金属对金属界面因存在不良软组织反应等潜在风险而引起了极大的关注,而金属锥部腐蚀这一问题更是成为近期瞩目的焦点,值得进一步深入研究。快速通道关节外科的迅速发展使得各种微创入路全髋关节置换手术再次赢得重视,但必须看到不可避免的学习曲线问题和微创技术本身可能存在的技术上的风险。在髋关节假体周围感染方面,目前的研究热点主要集中在感染的及时正确诊断和感染的积极预防上,多种新的诊断方法和具有抗菌或抑菌作用的新材料正被尝试用于感染的诊断和预防。各种高度多孔金属材料的临床应用改变了以往对于严重骨缺损的重建方法,为髋关节翻修带来了极大的便利。
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改良型Dewar手术治疗肩锁关节完全脱位及术后的关节功能恢复
BACKGROUND:Many scholars have reported the clinical practices and effect of Dewar operation,otherwise pain and dysfunction often occur after operation.