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The effect of Batroxobin expression of neural cell adhesion molecule (NCAM) in left temporal ischemic rats with spatial memory disorder was investigated by means of Morri's water maze and immunohistochemical methods. The results showed that the mean reaction time and distance of temporal ischemic rats for searching a goal were significantly longer than those of sham-operated rats and at the same time NCAM expression of left temporal ischemic region was significantly increased. However, the mean reaction time and distance of Batroxobin-treated rats were shorter and they used normal strategies more often and earlier than those of ischemic rats. The number of NCAM immune reactive cells of Batroxobin-treated rats was more than that of ischemic group. In conclusion, Batroxobin can improve spatial memory disorder of temporal ischemic rats and the regulation of the expression of NCAM is probably related to the neuroprotective mechanism.
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Morris水迷宫实验影响因素的研究进展
20世纪80年代初,Morris发明了水迷宫(Morris water maze,MWM)这种测量空间学习和记忆能力的实验方法,可用来评估啮齿动物由于衰老、药物和外伤等因素所造成的影响,并且该装置的使用简便易学,目前已被认为是此类研究的经典程序.其方法看似简单,但实验结果实则易受诸多因素的影响.为此,本文总结国内外的相关文献,从实验动物、环境和仪器设备、实验过程以及统计方法等几方面对水迷宫实验的影响进行一系统归纳和整理,以期对该法的科学应用有所裨益.
